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IMB-6G

N-substituted sophoridinic acid derivative with potent cytotoxicity against tumor cells

Networked: 3 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Halogenated Hydrocarbons: 42
    - Mustard Compounds: 3
      - Nitrogen Mustard Compounds: 2
        IMB-6G: 3

Experts

1.	Bi, Chongwen: 2 articles (01/2017 - 04/2016)
2.	Deng, Hongbin: 2 articles (01/2017 - 04/2016)
3.	Dou, Yueying: 2 articles (01/2017 - 04/2016)
4.	Liu, Lu: 2 articles (01/2017 - 04/2016)
5.	Pang, Weiqiang: 2 articles (01/2017 - 04/2016)
6.	Song, Danqing: 2 articles (01/2017 - 04/2016)
7.	Zhang, Na: 2 articles (01/2017 - 04/2016)
8.	Gong, Liang: 1 article (11/2018)
9.	Hu, Boxia: 1 article (11/2018)
10.	Pan, Yeting: 1 article (11/2018)

Related Diseases

1.	Hepatocellular Carcinoma (Hepatoma) 04/26/2016 - "In the present study, we explored the antitumor abilities of IMB-6G in human hepatocellular carcinoma (HCC) cells and investigated the underlying mechanisms. "
2.	Nasopharyngeal Carcinoma 11/01/2018 - "The purpose of the present study was to investigate the effect and underlying mechanism of IMB-6G on human nasopharyngeal carcinoma (NPC) cells. " 11/01/2018 - "IMB-6G induces endoplasmic reticulum stress-mediated apoptosis in human nasopharyngeal carcinoma cells."
3.	Neoplasms (Cancer) 04/26/2016 - "IMB-6G is a novel N-substituted sophoridinic acid derivative with potent cytotoxicity against tumor cells. " 01/01/2017 - "Our previous work showed that IMB-6G is a novel N-substituted sophoridinic acid derivative with potent cytotoxicity against tumor cells, yet the effect of IMB-6G on autophagy and pancreatic cancer cell death remains unknown. "
4.	Pancreatic Neoplasms (Pancreatic Cancer) 01/01/2017 - "IMB-6G promotes autophagosome accumulation from the early stage of treatment but blocks autophagic flux in the degradation stage, mainly through attenuation of lysosomal cathepsin activity in pancreatic cancer cells. " 01/01/2017 - "Here, we show that IMB-6G inhibits the growth of MiaPaCa-2 and HupT-3 pancreatic cancer cells and induces caspase-mediated apoptosis, which is correlated with an accumulation of autophagic vacuoles. " 01/01/2017 - "Our previous work showed that IMB-6G is a novel N-substituted sophoridinic acid derivative with potent cytotoxicity against tumor cells, yet the effect of IMB-6G on autophagy and pancreatic cancer cell death remains unknown. " 01/01/2017 - "Altogether, our findings demonstrate that IMB-6G is a novel autophagy inhibitor, which induces autophagy-dependent apoptosis through autophagosomal-cathepsin axis in pancreatic cancer cells and indicate the potential value of IMB-6G as a novel antitumor drug candidate."

Related Drugs and Biologics

1.	sophoridinic acid
2.	Caspases
3.	Cathepsins
4.	Antineoplastic Agents (Antineoplastics)