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TAT-Gap19 peptide

A nonapeptide derived from the cytoplasmic loop of connexin 43 (Cx43); inhibits Cx43 hemichannels

Also Known As:

TAT-Gap19

Networked: 9 relevant articles (1 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Membrane Transport Proteins: 589
      - Connexins: 2085
        Connexin 43: 2666
        TAT-Gap19 peptide: 9
- Peptides: 82426
  - Peptide Fragments: 373
    - TAT-Gap19 peptide: 9

Experts

1.	Leybaert, Luc: 4 articles (11/2019 - 01/2018)
2.	Vinken, Mathieu: 2 articles (03/2018 - 01/2018)
3.	Darvishmolla, Mahgol: 1 article (01/2022)
4.	Heysieattalab, Soomaayeh: 1 article (01/2022)
5.	Hosseinmardi, Narges: 1 article (01/2022)
6.	Janahmadi, Mahyar: 1 article (01/2022)
7.	Saeedi, Negin: 1 article (01/2022)
8.	Barbot, Manon: 1 article (10/2020)
9.	Barbouche, Rym: 1 article (10/2020)
10.	Brézun, Jean-Michel: 1 article (10/2020)

Related Diseases

1.	Tremor (Tremors) 01/01/2022 - "Results showed that animals receiving TAT-Gap19 before morphine injection demonstrated a significant reduction in several signs of morphine withdrawal such as Activity, Freezing, Chewing, Ptosis, Defecation, Teeth chattering, Writhing, Penis- licking, Head tremor, Scratching, Sniffing, Rearing, and Diarrhea (One way ANOVA, P < 0.001; P < 0.01; P < 0.05). "
2.	Diarrhea 01/01/2022 - "Results showed that animals receiving TAT-Gap19 before morphine injection demonstrated a significant reduction in several signs of morphine withdrawal such as Activity, Freezing, Chewing, Ptosis, Defecation, Teeth chattering, Writhing, Penis- licking, Head tremor, Scratching, Sniffing, Rearing, and Diarrhea (One way ANOVA, P < 0.001; P < 0.01; P < 0.05). "
3.	Atherosclerosis 10/14/2022 - "Inhibition of MST1 by oscillatory shear stress led to reduced phosphorylation of Cx43 (connexin 43) at Ser255, the Cx43 hemichannel open, EC activation, and atherosclerosis, which were blocked by TAT-GAP19, a Cx43 hemichannel inhibitory peptide. "
4.	Sepsis (Septicemia) 01/01/2018 - "Two well-known Cx43 mimetic peptides, the GAP26 and TAT-GAP19, divergently affected macrophage hemichannel activities in vitro, and differentially altered the outcome of lethal sepsis in vivo. "
5.	Seizures (Absence Seizure) 01/01/2018 - "We therefore investigated whether TAT-Gap19, a Cx mimetic peptide that inhibits Cx43 HCs but not the corresponding Cx43 GJCs, influences experimentally induced seizures in rodents. " 01/01/2018 - "Moreover, the anticonvulsant action of TAT-Gap19 was reversed by exogenous D-serine administration, suggesting that Cx43 HC inhibition protects against seizures by lowering extracellular D-serine levels. "

Related Drugs and Biologics

1.	Morphine (MS Contin)
2.	Connexin 43 (Connexin43)
3.	Peptides (Polypeptides)
4.	Connexins
5.	Superoxide Dismutase
6.	Serine (L-Serine)
7.	Proteins (Proteins, Gene)
8.	Carbenoxolone
9.	Anticonvulsants (Antiepileptic Drugs)
10.	1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester