JMV2894

peptidomimetic agonist of the ghrelin (GHS-R1a) receptor; reduces effects of cisplatin-induced cachexia in rats

Also Known As:

(R)-N-(1-(5-(2-(1H-indol-3-yl)ethyl)-4-(2,4-dimethoxybenzyl)-4H-1,2,4-triazol-3-yl)-2-(1H-indol-3-yl)ethyl)piperidine-4-carboxamide trifluoroacetate salt; JMV-2894

Networked: 4 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Triazoles: 1533
      - JMV2894: 4
  - Piperidines: 17
    - JMV2894: 4
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Indoles: 200
      - JMV2894: 4

Experts

1.	Fehrentz, Jean-Alain: 3 articles (10/2017 - 06/2017)
2.	Liantonio, Antonella: 3 articles (10/2017 - 06/2017)
3.	Martinez, Jean: 3 articles (10/2017 - 06/2017)
4.	Rizzi, Laura: 3 articles (10/2017 - 06/2017)
5.	Torsello, Antonio: 3 articles (10/2017 - 06/2017)
6.	Camerino, Giulia Maria: 2 articles (10/2017 - 06/2017)
7.	Conte, Elena: 2 articles (10/2017 - 06/2017)
8.	Fonzino, Adriano: 2 articles (10/2017 - 06/2017)
9.	Ben Haj Salah, Khoubaib: 2 articles (10/2017 - 06/2017)
10.	Bresciani, Elena: 2 articles (10/2017 - 06/2017)

Related Diseases

1.	Neuroblastoma 01/04/2023 - "Protective Effects of Hexarelin and JMV2894 in a Human Neuroblastoma Cell Line Expressing the SOD1-G93A Mutated Protein."
2.	Body Weight (Weight, Body) 10/01/2017 - "Interestingly, rats which received JMV2894 demonstrated a faster gain in body weight than any other growth hormone secretagogues treated group and at the end of the protocol reached a weight similar to that of controls. " 10/01/2017 - "The purpose of this study was to investigate whether selected growth hormone secretagogues including hexarelin, JMV2894 and JMV2951 could antagonize body weight loss and wasting induced by cisplatin administration in rats. "
3.	Cachexia 10/01/2017 - "JMV2894, a novel growth hormone secretagogue, accelerates body mass recovery in an experimental model of cachexia." 10/01/2017 - "In conclusion, our findings demonstrate that JMV2894 antagonizes cisplatin induced weight loss in rats and may prove useful in antagonizing cachexia associated with cancer and chemotherapy in humans." 06/01/2017 - "By a multidisciplinary approach ranging from cytofluorometry and electrophysiology to gene expression and histology, we characterized the calcium homeostasis in fast-twitch extensor digitorum longus (EDL) muscle of adult rats with cisplatin-induced cachexia and established the potential beneficial effects of two GHS (hexarelin and JMV2894) at this level. " 10/12/2017 - "By using a rat model of cisplatin-induced cachexia, we here characterized the mitochondrial homeostasis in tibialis anterior cachectic muscle and evaluated the potential beneficial effects of the growth hormone secretagogues (GHS) hexarelin and JMV2894 in this setting. " 10/12/2017 - "Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia."
4.	Mitochondrial Diseases (Mitochondrial Disease) 10/12/2017 - "Importantly, JMV2894 and hexarelin are capable to antagonize this chemotherapy-induced mitochondrial dysfunction. "
5.	Weight Loss (Weight Reduction) 10/01/2017 - "In conclusion, our findings demonstrate that JMV2894 antagonizes cisplatin induced weight loss in rats and may prove useful in antagonizing cachexia associated with cancer and chemotherapy in humans."

Related Drugs and Biologics

1.	hexarelin
2.	Proteins (Proteins, Gene)
3.	Cisplatin (Platino)
4.	Growth Hormone (Somatotropin)
5.	Secretagogues
6.	Calcium

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)