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NC-4016

1,2-diaminocyclohexane platinum (II) (DACHPt)-incorporating micelles

Networked: 2 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Macromolecular Substances: 97
- Micelles: 4675
  - NC-4016: 2
Pharmaceutical Preparations
- Dosage Forms: 1139
  - Micelles: 4675
    - NC-4016: 2
Organic Chemicals: 133
- Organometallic Compounds: 64
  - Organoplatinum Compounds
    - NC-4016: 2

Experts

1.	Kataoka, Kazunori: 2 articles (12/2017 - 01/2014)
2.	Cabral, Horacio: 1 article (12/2017)
3.	Mochida, Yuki: 1 article (12/2017)
4.	Endo, Kazuhira: 1 article (01/2014)
5.	Hori, Kiyomi: 1 article (01/2014)
6.	Kato, Yasuki: 1 article (01/2014)
7.	Kondo, Satoru: 1 article (01/2014)
8.	Murono, Shigeyuki: 1 article (01/2014)
9.	Ozaki, Noriyuki: 1 article (01/2014)
10.	Tsuji, Akira: 1 article (01/2014)

Related Diseases

1.	Peripheral Nervous System Diseases (PNS Diseases) 01/01/2014 - "Moreover, we compared the severity of peripheral neuropathy induced by oxaliplatin and NC-4016 in a rat model. " 01/01/2014 - "The present study was designed to evaluate the efficacy of NC-4016 and its association with peripheral neuropathy, which is a primary dose-limiting factor in oxaliplatin therapy. "
2.	Neoplasms (Cancer) 12/01/2017 - "Expert opinion: NC-6004 and NC-4016 micelles meet critical structural and functional requirements for achieving safe and effective tumor targeting, enhancing efficacy even against drug resistant cancer cells, and have been translated into human studies, aiming to be the first-of-their-kind in the clinic. "
3.	Carcinoma (Carcinomatosis) 01/01/2014 - "The in vitro antitumor activity of NC-4016 was investigated using human carcinoma cell lines. " 01/01/2014 - "To investigate the antitumor effects of NC-4016 in vivo, nude mice bearing the human carcinoma cell line KB were administered NC-4016 or oxaliplatin. " 01/01/2014 - "The present study demonstrated that the antitumor efficacy of NC-4016 was superior to that of oxaliplatin in a mouse model of human carcinoma cell line KB. In addition, NC-4016-treated rats did not develop acute cold hypersensitivity, which is frequently experienced by patients after oxaliplatin administration. "
4.	Cold Hypersensitivity 01/01/2014 - "The present study demonstrated that the antitumor efficacy of NC-4016 was superior to that of oxaliplatin in a mouse model of human carcinoma cell line KB. In addition, NC-4016-treated rats did not develop acute cold hypersensitivity, which is frequently experienced by patients after oxaliplatin administration. "

Related Drugs and Biologics

1.	Micelles
2.	Oxaliplatin (Eloxatin)
3.	demplatin pegraglumer

Related Therapies and Procedures

1.	Therapeutics