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KDU731

an antiprotozoal agent; structure in first source

Networked: 3 relevant articles (1 outcomes, 0 trials/studies)

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Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Pyrazoles: 61
      - KDU731: 3
  - Pyridines: 88
    - KDU731: 3

Experts

1.	Chavez, Miguel A: 1 article (01/2018)
2.	White, A Clinton: 1 article (01/2018)
3.	Blasco, Francesca: 1 article (01/2017)
4.	Bodenreider, Christophe: 1 article (01/2017)
5.	Bonamy, Ghislain M C: 1 article (01/2017)
6.	Brooks, Carrie F: 1 article (01/2017)
7.	Chao, Alexander T: 1 article (01/2017)
8.	Diagana, Thierry T: 1 article (01/2017)
9.	Feng, Gu: 1 article (01/2017)
10.	Gedeck, Peter: 1 article (01/2017)

Related Diseases

1.	Diarrhea 01/01/2017 - "The pyrazolopyridine KDU731 is a promising drug candidate for treatment of diarrhea caused by Cryptosporidium in young children in the resource-limited world. " 01/01/2018 - "Inhibition of Plasmodium lipid kinase PI(4)K8 of Cryptosporidium by KDU731 greatly reduced oocyst shedding and improved diarrhea in calves with limited effects on the human PI(4)K. " 01/01/2017 - "KDU731, a PI (4) kinase inhibitor, blocks Cryptosporidium infection in vitro and in vivo in immunocompromised mice and dramatically reduces oocyst shedding, diarrhea, and dehydration in neonatal calves."
2.	Cryptosporidiosis 01/01/2017 - "Our results suggest that the Cryptosporidium lipid kinase PI(4)K (phosphatidylinositol-4-OH kinase) is a target for pyrazolopyridines and that KDU731 warrants further preclinical evaluation as a drug candidate for the treatment of cryptosporidiosis." 01/01/2017 - "KDU731, a PI (4) kinase inhibitor, blocks Cryptosporidium infection in vitro and in vivo in immunocompromised mice and dramatically reduces oocyst shedding, diarrhea, and dehydration in neonatal calves."
3.	Infections 01/01/2017 - "Oral treatment with the pyrazolopyridine KDU731 results in a potent reduction in intestinal infection of immunocompromised mice. "
4.	Dehydration (Water Stress) 01/01/2017 - "KDU731, a PI (4) kinase inhibitor, blocks Cryptosporidium infection in vitro and in vivo in immunocompromised mice and dramatically reduces oocyst shedding, diarrhea, and dehydration in neonatal calves."

Related Drugs and Biologics

1.	Phosphotransferases (Kinase)
2.	Lipids
3.	pyrazolopyridine
4.	1-Phosphatidylinositol 4-Kinase (1 Phosphatidylinositol 4 Kinase)