physapubenolide

has antineoplastic activity; isolated from Physalis angulata; structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

1.	Neoplasms (Cancer) 06/01/2022 - "Physapubenolide (PB), a withanolide-type compound extracted from the traditional herb Physalis minima L., has been demonstrated to exert remarkable cytotoxicity against cancer cells; however, its molecular mechanisms are still unclear. "
2.	Melanoma (Melanoma, Malignant) 06/01/2022 - "Identification of HMGCR as the anticancer target of physapubenolide against melanoma cells by in silico target prediction."
3.	Hepatocellular Carcinoma (Hepatoma) 01/01/2016 - "Metabonomics applied in exploring the antitumour mechanism of physapubenolide on hepatocellular carcinoma cells by targeting glycolysis through the Akt-p53 pathway."
4.	Breast Neoplasms (Breast Cancer) 11/01/2017 - "Downregulation of TIGAR sensitizes the antitumor effect of physapubenolide through increasing intracellular ROS levels to trigger apoptosis and autophagosome formation in human breast carcinoma cells."