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aquachloro(bis(2- pyridylmethyl)amino- 2- propionic acid)manganese(II)

an anti-glioma agent; structure in first source

Also Known As:

((Adpa)Mn(Cl)(H2O)); Adpa-Mn

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Inorganic Chemicals: 9
- Coordination Complexes: 576
  - aquachloro(bis(2-pyridylmethyl)amino-2-propionic acid)manganese(II): 2
Organic Chemicals: 133
- Coordination Complexes: 576
  - aquachloro(bis(2-pyridylmethyl)amino-2-propionic acid)manganese(II): 2

Experts

1.	Chen, Qiuyun: 1 article (03/2015)
2.	Gao, Jing: 1 article (03/2015)
3.	Geng, Ji: 1 article (03/2015)
4.	Guo, Wenjie: 1 article (03/2015)
5.	Li, Jing: 1 article (03/2015)
6.	Li, Xiang: 1 article (03/2015)
7.	Liu, Jia: 1 article (03/2015)
8.	Dong-Fang, Zhou: 1 article (11/2010)
9.	Jing, Gao: 1 article (11/2010)
10.	Juan, Huang: 1 article (11/2010)

Related Diseases

1.	Neoplasms (Cancer) 03/01/2015 - "In vivo, the induction of apoptosis and autophagy in tumor tissue was confirmed following treatment with Adpa-Mn, which contributed to its significant antitumor activity against hepatocellular carcinoma (Hep-A cell) xenografts at 10 mg/kg. Taken together, these data suggest the possible use of Adpa-Mn as a novel anticancer drug." 03/01/2015 - "We then found that Adpa-Mn achieved its selectivity against cancer cells through the transferrin (Tf)-transferrin receptor (TfR) system, which is highly expressed in tumor cells. "
2.	Hepatocellular Carcinoma (Hepatoma) 03/01/2015 - "In vivo, the induction of apoptosis and autophagy in tumor tissue was confirmed following treatment with Adpa-Mn, which contributed to its significant antitumor activity against hepatocellular carcinoma (Hep-A cell) xenografts at 10 mg/kg. Taken together, these data suggest the possible use of Adpa-Mn as a novel anticancer drug."
3.	Glioma (Gliomas) 11/01/2010 - "Especially [(Adpa)Mn(Cl)(H(2)O)] can inhibit the proliferation of glioma cells with IC(50) 9.5 μM. "

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