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SF1670

a PTEN inhibitor; structure in first source

Networked: 8 relevant articles (2 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenanthrenes: 27
        SF1670: 8
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - SF1670: 8

Experts

1.	Karimi, Pouran: 2 articles (01/2018 - 01/2018)
2.	Peng, Yu-Fen: 1 article (09/2021)
3.	Sun, Lan: 1 article (09/2021)
4.	Wu, Xu-Xian: 1 article (09/2021)
5.	Bai, Yuping: 1 article (01/2021)
6.	Jiang, Hong-Sheng: 1 article (01/2021)
7.	Liu, Honggang: 1 article (01/2021)
8.	Liu, Yang: 1 article (01/2021)
9.	Niu, Hai-Tao: 1 article (01/2021)
10.	Piao, Yingshi: 1 article (01/2021)

Related Diseases

1.	Neutropenia 06/16/2011 - "Together, these observations demonstrate that the innate immune responses can be enhanced and the severity of neutropenia-related infection can be alleviated by augmenting phosphatidylinositol (3,4,5)-trisphosphate in transfused neutrophils with PTEN inhibitor SF1670, providing a therapeutic strategy for improving the efficacy of granulocyte transfusion."
2.	Infections 06/16/2011 - "Together, these observations demonstrate that the innate immune responses can be enhanced and the severity of neutropenia-related infection can be alleviated by augmenting phosphatidylinositol (3,4,5)-trisphosphate in transfused neutrophils with PTEN inhibitor SF1670, providing a therapeutic strategy for improving the efficacy of granulocyte transfusion."
3.	Infarction (Infarctions) 06/01/2019 - "Pharmacological postconditioning induced with CGS21680 and SF1670 attenuated the infarction along with improved behavioural and biochemical parameters in comparison with ischaemia-reperfusion control group. "
4.	Stroke (Strokes) 01/01/2018 - "The current study aimed to examine the impact of SF1670, a potent PTEN inhibitor, on mitochondria-mediated cell survival pathways in an in vitro stroke-like model. " 01/01/2018 - "In this study, we investigated the neuroprotective effect of SF1670, as a new PTEN inhibitor, on an in vitro stroke-like model. "
5.	Intervertebral Disc Degeneration 01/01/2020 - "SF1670 inhibits apoptosis and inflammation via the PTEN/Akt pathway and thus protects intervertebral disc degeneration."

Related Drugs and Biologics

1.	Phosphatidylinositols (Phosphatidylinositol)
2.	2- (4- (2- carboxyethyl)phenethylamino)- 5'- N- ethylcarboxamidoadenosine
3.	Neuroprotective Agents
4.	Small Interfering RNA (siRNA)
5.	Proteins (Proteins, Gene)
6.	Collagen
7.	columbamine