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ZBH-1205

has antineoplastic activity; structure in first source

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- Alkaloids: 5398
  - Camptothecin: 2033
    - ZBH-1205: 1

Experts

1.	Chen, Zhijia: 1 article (01/2016)
2.	Lan, Shijie: 1 article (01/2016)
3.	Shi, Weiguo: 1 article (01/2016)
4.	Tai, Jiandong: 1 article (01/2016)
5.	Wei, Zhengren: 1 article (01/2016)
6.	Wu, Di: 1 article (01/2016)
7.	Yu, Hong: 1 article (01/2016)
8.	Zhao, Dawei: 1 article (01/2016)
9.	Zhao, Jing: 1 article (01/2016)
10.	Zhong, Bohua: 1 article (01/2016)

Related Diseases

1.

Neoplasms (Cancer)

01/01/2016 - "Furthermore, ZBH-1205 was more effective than CPT-11 or SN38 at stabilizing Topo-1-DNA complexes and inducing tumor cell apoptosis. "
01/01/2016 - "Here, the in vitro anti-tumor activity and associated mechanisms of a novel derivative of camptothecin, ZBH-1205, were investigated in a panel of 9 human tumor cell lines, as well as in HEK 293 and SK-OV-3/DPP, a multi-drug resistant (MDR) cell line, and compared to CPT-11 and 7-ethyl-10-hydroxy-camptothecin (SN38). "

Related Drugs and Biologics

1.	Camptothecin
2.	Irinotecan (Camptosar)