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9R-P201

inhibits the viability, proliferation and migration of liver cancer HepG2 cells

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - 9R-P201: 2

Experts

1.	Guo, Zhiyun: 2 articles (11/2017 - 02/2017)
2.	Liu, Wenrong: 2 articles (11/2017 - 02/2017)
3.	Mao, Canquan: 2 articles (11/2017 - 02/2017)
4.	Xiong, Lili: 2 articles (11/2017 - 02/2017)
5.	Ding, Ruofan: 1 article (11/2017)
6.	Huang, Qingqing: 1 article (11/2017)
7.	Kang, Ran: 1 article (11/2017)
8.	Meng, Junhua: 1 article (11/2017)
9.	Zhang, Yiming: 1 article (11/2017)
10.	Bi, Zhenfei: 1 article (02/2017)

Related Diseases

1.	Neoplasms (Cancer) 02/05/2017 - "Thus, 9R-P201 holds great potential as a lead anti-cancer drug targeting FoxM1." 02/05/2017 - "Finally, treatment of HepG2 xenografts with 9R-P201 resulted in growth inhibition and down-regulation of foxM1 expression in tumors. " 02/05/2017 - "Here in this paper, we found that 9R-P201, one of the novel peptides, showed stronger inhibition to HepG2 cancer cells than those of DU145, HUVEC and L-02 cells with an IC50 of 43.6µg/ml (13.1µM). "
2.	Liver Neoplasms (Liver Cancer) 02/05/2017 - "Collectively, our findings suggested that 9R-P201 could strongly inhibit the viability, proliferation and migration of liver cancer HepG2 cells and induce apoptosis by down-regulation of FoxM1 and regulation of related gene expression in signal transduction passways. " 02/05/2017 - "The peptide was highly effective to liver cancer cells with an IC50 for L-02 cells of 2855.9µg/ml. We confirmed that 9R-P201 aggregated in the cell nucleus and the expression of FoxM1 was significantly down-regulated at both transcriptional and translational levels in HepG2 cells, leading to the suppression of cell proliferation, migration, angiogenesis, and induction of apoptosis. " 02/05/2017 - "A novel peptide, 9R-P201, strongly inhibits the viability, proliferation and migration of liver cancer HepG2 cells and induces apoptosis by down-regulation of FoxM1 expression."
3.	Hepatocellular Carcinoma (Hepatoma) 11/01/2017 - "These findings offer novel insights into the mechanism of 9R-P201 in HepG2 cells and provide new opportunities for the future 9R-P201-based drug development and the treatment of hepatocellular carcinoma." 11/01/2017 - "To characterize the transcriptome profile of hepatocellular carcinoma (HCC) HepG2 cells treated with peptide 9R-P201 for further functional verification and HCC drug development. "

Related Drugs and Biologics

1.	Peptides (Polypeptides)