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JTE-852

a spleen tyrosine kinase inhibitor; structure in first source

Also Known As:

2-methyl-2-(1-(5-(6-(4-methylpyridin-2-ylamino)pyridin-2-yl)thiazol-2-yl)piperidin-4-yl)propanoic acid

Networked: 3 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Amines: 4871
  - Aminopyridines: 77
    - JTE-852: 3
- Sulfur Compounds: 278
  - Thiazoles: 392
    - JTE-852: 3
Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Azoles: 2138
    - Thiazoles: 392
      - JTE-852: 3
  - Pyridines: 88
    - Aminopyridines: 77
      - JTE-852: 3

Experts

1.	Hata, Takahiro: 3 articles (03/2018 - 04/2017)
2.	Iwasaki, Hidenori: 3 articles (03/2018 - 04/2017)
3.	Kato, Toshinobu: 3 articles (03/2018 - 04/2017)
4.	Kobayashi, Hatsue: 3 articles (03/2018 - 04/2017)
5.	Matsuo, Akira: 3 articles (03/2018 - 04/2017)
6.	Matsushita, Mutsuyoshi: 3 articles (03/2018 - 04/2017)
7.	Ohta, Takeshi: 2 articles (03/2018 - 12/2017)
8.	Miyagawa, Naoki: 1 article (04/2017)

Related Diseases

1.	Hypersensitivity (Allergy) 04/15/2017 - "The results suggest that JTE-852 is supposed to prevent various allergic reactions caused by the three group mediators in vivo. " 04/15/2017 - "In fact, oral gavage of JTE-852 attenuated an allergic reaction mediated by histamine, which is a representative of the three groups of mediators. " 03/24/2018 - "In the present study, we investigated the effects of JTE-852 in four rat models (sneezing, rhinorrhea, airway constriction, and airway inflammation) as representatives of allergy models. " 03/24/2018 - "JTE-852 showed significant blocking effects on antigen-induced allergic reactions in all models, indicating that JTE-852 in oral dosage form would improve a wide range of allergic signs. " 03/24/2018 - "JTE-852, a novel spleen tyrosine kinase inhibitor, blocks antigen-induced allergic reactions in rats."
2.	Sneezing 03/24/2018 - "In the present study, we investigated the effects of JTE-852 in four rat models (sneezing, rhinorrhea, airway constriction, and airway inflammation) as representatives of allergy models. "
3.	Inflammation (Inflammations) 03/24/2018 - "In the present study, we investigated the effects of JTE-852 in four rat models (sneezing, rhinorrhea, airway constriction, and airway inflammation) as representatives of allergy models. "
4.	Rhinorrhea 03/24/2018 - "In the present study, we investigated the effects of JTE-852 in four rat models (sneezing, rhinorrhea, airway constriction, and airway inflammation) as representatives of allergy models. "
5.	Edema (Dropsy) 12/15/2017 - "In the RCA and RPA models, JTE-852 also suppressed edema and dye leakage, respectively. "

Related Drugs and Biologics

1.	Methotrexate (Mexate)
2.	Immunoglobulin G (IgG)
3.	Histamine (Histamine Dihydrochloride)
4.	Coloring Agents (Dyes)
5.	Dosage Forms (Dosage Form)
6.	Antigens
7.	Syk Kinase