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estafietin

inhibits meiosis in amphibian ooxytes; isolated from Stevia alpina; structure in first source

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Sesquiterpenes: 1370
      - Polycyclic Sesquiterpenes: 9
        Eudesmane Sesquiterpenes: 2
        Guaiane Sesquiterpenes: 5
        estafietin: 3
  - Cyclic Hydrocarbons: 97
    - Alicyclic Hydrocarbons: 1
      - Cycloparaffins: 6
        Cycloheptanes
        Guaiane Sesquiterpenes: 5
        estafietin: 3
Polycyclic Compounds: 6
- Polycyclic Sesquiterpenes: 9
  - Eudesmane Sesquiterpenes: 2
    - Guaiane Sesquiterpenes: 5
      - estafietin: 3

Experts

1.	Elso, Orlando G: 2 articles (02/2022 - 03/2019)
2.	Sülsen, Valeria P: 2 articles (02/2022 - 03/2019)
3.	Barrera, Patricia: 1 article (02/2022)
4.	Lombardo, María E: 1 article (02/2022)
5.	Puente, Vanesa: 1 article (02/2022)
6.	Sosa-Escudero, Miguel A: 1 article (02/2022)
7.	Bivona, Augusto E: 1 article (03/2019)
8.	Catalán, César A N: 1 article (03/2019)
9.	Cazorla, Silvia I: 1 article (03/2019)
10.	Cerny, Natacha: 1 article (03/2019)

Related Diseases

1.	Chagas Disease (American Trypanosomiasis) 03/20/2023 - "The aim of this work was to predict the toxicologic profile of estafietin by in silico methods and assess its in vivo activity on a murine model of Chagas disease. " 02/01/2022 - "The treatment combining eupatoriopicrin and estafietin could be considered a promising alternative for the treatment of Chagas' disease." 03/28/2019 - "The antiparasitic activity demonstrated by estafietin and some of its derivatives make them promising candidates for the development of effective compounds for the treatment of Chagas disease and leihsmaniasis."
2.	Parasitemia 03/20/2023 - "The treatment of infected mice with 1 mg/Kg/day of estafietin for five consecutive days administrated by intraperitoneal route significatively decreased parasitemia levels and reduced inflammatory infiltrates and myocyte damage on muscle tissue. "
3.	Infections 03/20/2023 - "These results suggest that estafietin had effect both on acute and chronic stages of the infection."

Related Drugs and Biologics

1.	Antiparasitic Agents (Antiparasitics)
2.	eupatoriopicrine