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paeoniflorin-6'-O-benzenesulfonate

has anti-inflammatory activity

Also Known As:

CP-25 compound; paeoniflorin-6'-O-benzene sulfonate

Networked: 16 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Glucosides: 639
    - paeoniflorin-6'-O-benzenesulfonate: 16
Organic Chemicals: 133
- Hydrocarbons: 1713
  - Terpenes: 1461
    - Monoterpenes: 522
      - paeoniflorin-6'-O-benzenesulfonate: 16

Experts

1.	Wei, Wei: 12 articles (07/2022 - 01/2016)
2.	Wang, Chun: 5 articles (07/2022 - 01/2016)
3.	Chang, Yan: 4 articles (07/2022 - 01/2016)
4.	Chen, Jing-Yu: 3 articles (12/2021 - 06/2019)
5.	Zhang, Ling-Ling: 3 articles (12/2021 - 06/2019)
6.	Wu, Yu-Jing: 3 articles (08/2019 - 01/2018)
7.	Jiang, Meng-Ya: 2 articles (12/2021 - 01/2020)
8.	Han, Le: 2 articles (02/2021 - 06/2019)
9.	Shu, Jin-Ling: 2 articles (02/2021 - 06/2019)
10.	Tai, Yu: 2 articles (02/2021 - 06/2019)

Related Diseases

1.	Arthritis (Polyarthritis) 07/01/2022 - "Paeoniflorin-6'-o-benzene sulfonate ameliorates the progression of adjuvant-induced arthritis by inhibiting the interaction between Ahr and GRK2 of fibroblast-like synoviocytes." 01/01/2022 - "Paeoniflorin-6'-O-benzene sulfonate (CP-25) has proven to have critical anti-inflammatory effects in arthritis. " 04/01/2019 - "Methotrexate improves the anti-arthritic effects of Paeoniflorin-6'-O-benzene sulfonate by enhancing its pharmacokinetic properties in adjuvant-induced arthritis rats." 01/01/2016 - "Paeoniflorin-6'-O-benzene sulfonate (code: CP-25), a novel ester derivative of paeoniflorin (Pae), was evaluated in rats with adjuvant-induced arthritis (AA) to study its potential anti-arthritic activity. "
2.	Rheumatoid Arthritis 01/01/2020 - "This study aims to explore the effect of paeoniflorin-6'-O-benzene sulfonate (CP-25) on the migration of fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) and the mechanism focused on CXCR4-Gβγ-PI3K/AKT signaling. " 01/01/2023 - "T helper type 17 (Th17) cell which is induced by interleukine-6 (IL-6)-signal transducers and activators of transcription 3 (STAT3) signaling is a central pro-inflammatory T cell subtype in rheumatoid arthritis (RA) and could be significantly reduced by paeoniflorin-6'-O-benzene sulfonate (CP-25) treatment with unclear mechanisms. " 01/01/2020 - "Paeoniflorin-6'-O-benzene sulfonate down-regulates CXCR4-Gβγ-PI3K/AKT mediated migration in fibroblast-like synoviocytes of rheumatoid arthritis by inhibiting GRK2 translocation." 08/01/2019 - "Paeoniflorin-6'-O-benzene sulfonate (CP-25) is a novel compound derived from paeoniflorin that has been demonstrated to have therapeutic effects in a rat model of rheumatoid arthritis (RA). "
3.	Inflammation (Inflammations) 11/15/2020 - "Paeoniflorin-6'-O-benzene sulfonate (CP-25) is known to suppress inflammation and atherogenesis. " 01/01/2018 - "Paeoniflorin-6'-O-benzene sulfonate (code: CP-25), the chemistry structural modifications of paeoniflorin, was a novel drug of anti-inflammation and immunomodulation. " 01/01/2019 - "The Regulatory Effects of Paeoniflorin and Its Derivative Paeoniflorin-6'-O-Benzene Sulfonate CP-25 on Inflammation and Immune Diseases." 11/30/2023 - "Inhibiting the activity of GRK2 with the novel GRK2 inhibitor paeoniflorin-6'-O-benzene sulfonate (CP-25), a derivative of paeoniflorin, or the accepted GRK2 inhibitor paroxetine effectively reversed the switch in Gαs-Gαi coupling to β2AR during inflammation and restored the intracellular cAMP level in ISO-stimulated FLSs. "
4.	Experimental Arthritis 06/01/2019 - "Paeoniflorin-6'-O-benzene sulfonate alleviates collagen-induced arthritis in mice by downregulating BAFF-TRAF2-NF-κB signaling: comparison with biological agents." 01/01/2020 - "Paeoniflorin-6'-O-benzene sulfonate (CP-25), as a novel ester derivative of paeoniflorin (pae), has therapeutic potential for the treatment of adjuvant arthritis (AA) and collagen-induced arthritis (CIA), but the underlying mechanism of CP-25 on angiogenesis has not been elucidated. "
5.	Atherosclerosis 11/15/2020 - "Paeoniflorin-6'-O-benzene sulfonate (CP-25) is known to suppress inflammation and atherogenesis. "

Related Drugs and Biologics

1.	peoniflorin
2.	Esters
3.	Therapeutic Uses
4.	Paroxetine (Paxil)
5.	Methotrexate (Mexate)

Related Therapies and Procedures

1.	Immunomodulation