5- (3- (4- (4- benzylpiperazin- 1- yl)- N- (4- phenylthiazol- 2- yl))propanamide

01/01/2019 - "However, the loss of the epithelium and airway obstruction were significantly improved in mice treated with TJ-M2010-5 combined with MR-1. "

02/25/2022 - "TJ-M2010-5, A self-developed MyD88 inhibitor, attenuates liver fibrosis by inhibiting the NF-κB pathway."
02/25/2022 - "In conclusion, this study illustrates the anti-hepatic fibrosis effect of TJ-M2010-5 and provides a new treatment method for liver fibrosis."
02/25/2022 - "In the present study, to investigate the anti-fibrotic effect of TJ-M2010-5, mice were injected with carbon tetrachloride (CCl4) in vivo and LX2 cells (a human hepatic stellate cell line) were treated with TGF-β1 in vitro to induce liver fibrosis. "

02/25/2022 - "In conclusion, this study illustrates the anti-hepatic fibrosis effect of TJ-M2010-5 and provides a new treatment method for liver fibrosis."

01/01/2023 - "The Novel MyD88 Inhibitor TJ-M2010-5 Protects Against Hepatic Ischemia-reperfusion Injury by Suppressing Pyroptosis in Mice."
04/01/2022 - "Hypothermic oxygenated perfusion combined with TJ-M2010-5 alleviates hepatic ischemia-reperfusion injury in donation after circulatory death."
01/01/2022 - "TJ-M2010-5, a novel CNS drug candidate, attenuates acute cerebral ischemia-reperfusion injury through the MyD88/NF-κB and ERK pathway."
12/01/2022 - "TJ-M2010-5 Attenuates Severe Myocardial Ischemia/Reperfusion Injury in Heart Transplantation by Inhibiting MyD88 Homodimerization In Vivo."
12/01/2022 - "In a cardiac cold ischemia/reperfusion model, TJ-M2010-5 ameliorated myocardial ischemia/reperfusion injury (MIRI) in histidine-tryptophan-ketoglutarate (HTK) organ preservation solution. "

10/01/2019 - "More importantly, TJ-M2010-5 significantly inhibited tumor growth in mice. "
10/01/2019 - "The antitumor effect of intratumoral injection of TJ-M2010-5 to H22 tumor-bearing BALB/c mice was observed. "
01/01/2019 - "Here, we describe the mechanisms of the novel MyD88 inhibitor, TJ-M2010-5, and the discovery of its immunosuppressive properties in the context of GVHD and the graft-versus-tumor (GVT) effect in a fully MHC-mismatched murine model. "
10/01/2019 - "To explore the potential of TJ-M2010-5 in tumor therapy, we determined its antitumor effect and correlate mechanisms of TJ-M2010-5 in hepatocellular carcinoma (HCC). "
04/01/2016 - "We utilized a mouse model of azoxymethane/dextran sodium sulfate (AOM/DSS)-induced colitis-associated cancer (CAC) in combination with TJ-M2010-5 administration to investigate the anti-inflammation-related cancer effect of MyD88 inhibitor in vivo. "