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NAX 5055

a palmitoylated form of galanin (1-13) in which the C-terminus has been extended with cationic residues; has anticonvulsant activity

Also Known As:

Gal-B2 peptide; NAX-5055

Networked: 4 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Nerve Tissue Proteins: 2
    - Neuropeptides: 6772
      - Galanin: 931
        NAX 5055: 4
- Peptides: 82426
  - Neuropeptides: 6772
    - Galanin: 931
      - NAX 5055: 4
  - Lipopeptides: 626
    - NAX 5055: 4
Lipids: 114793
- Lipopeptides: 626
  - NAX 5055: 4

Experts

1.	White, H Steve: 3 articles (01/2019 - 04/2009)
2.	Bulaj, Grzegorz: 2 articles (01/2019 - 04/2009)
3.	Klein, Brian D: 2 articles (01/2014 - 04/2009)
4.	Nowik, Natalia: 1 article (01/2021)
5.	Podlasz, Piotr: 1 article (01/2021)
6.	Prajsnar, Tomasz K: 1 article (01/2021)
7.	Przyborowska, Anna: 1 article (01/2021)
8.	Rakus, Krzysztof: 1 article (01/2021)
9.	Sienkiewicz, Waldemar: 1 article (01/2021)
10.	Spaink, Herman P: 1 article (01/2021)

Related Diseases

1.	Staphylococcal Infections 01/01/2021 - "We showed that knockout of galanin in zebrafish leads to a higher bacterial burden and mortality during Mycobacterium marinum and Staphylococcus aureus infection, whereas administration of a galanin analogue, NAX 5055, improves the ability of fish to control the infection caused by both pathogens. "
2.	Infantile Spasms (West Syndrome) 01/01/2014 - "In conclusion, a single dose of NAX 5055 has no acute efficacy on spasms or toxicity in the multiple hit rat model of medically refractory infantile spasms. " 01/01/2014 - "Efficacy and tolerability of the galanin analog NAX 5055 in the multiple-hit rat model of symptomatic infantile spasms."
3.	Spasm (Spasms) 01/01/2014 - "Our findings cannot exclude the possibility that repetitive NAX 5055 administration may show efficacy on spasms. " 01/01/2014 - "There was no acute effect of NAX 5055 on spasm frequency after the single dose of NAX 5055 (n=11-13 rats/group, following exclusions). " 01/01/2014 - "In conclusion, a single dose of NAX 5055 has no acute efficacy on spasms or toxicity in the multiple hit rat model of medically refractory infantile spasms. " 01/01/2014 - "Here, we are testing the efficacy and tolerability of a single dose of the galanin receptor 1 preferring analog, NAX 5055, in the multiple-hit model of spasms. "
4.	Seizures (Absence Seizure) 04/01/2009 - "Our efforts to engineer galanin analogs that can penetrate the blood-brain-barrier and suppress seizures, yielded NAX 5055 (Gal-B2), a systemically-active analog that maintains low nanomolar affinity for galanin receptors and displays a potent anticonvulsant activity. "
5.	Infections 01/01/2021 - "We showed that knockout of galanin in zebrafish leads to a higher bacterial burden and mortality during Mycobacterium marinum and Staphylococcus aureus infection, whereas administration of a galanin analogue, NAX 5055, improves the ability of fish to control the infection caused by both pathogens. "

Related Drugs and Biologics

1.	Galanin
2.	Type 1 Galanin Receptor
3.	Galanin Receptors (Galanin Receptor)
4.	Ibuprofen (Motrin)
5.	Cannabidiol
6.	Anticonvulsants (Antiepileptic Drugs)
7.	Analgesics (Analgesic Drugs)
8.	Levetiracetam (Keppra)