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4- amino- 6- (3- (3- bromophenyl)phenyl)- 7- (xylofuranosyl)pyrolo(2,3- d)pyrimidine- 5- nitrile

has antineoplastic activity; structure in first source

Also Known As:

4-amino-6-(3-(3-bromophenyl)phenyl)-7-(xylofuranosyl)pyrolo(2,3-d)pyrimidine-5-cyano; JRS-15

Networked: 1 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Carbohydrates: 22023
- Glycosides: 2119
  - Nucleosides: 6847
    - 4-amino-6-(3-(3-bromophenyl)phenyl)-7-(xylofuranosyl)pyrolo(2,3-d)pyrimidine-5-nitrile: 1
Nucleic Acids, Nucleotides, and Nucleosides: 1
- Nucleosides: 6847
  - 4-amino-6-(3-(3-bromophenyl)phenyl)-7-(xylofuranosyl)pyrolo(2,3-d)pyrimidine-5-nitrile: 1

Experts

1.	Bai, Xiao: 1 article (01/2013)
2.	Guo, Xiao-Xi: 1 article (01/2013)
3.	Jin, Ying-Hua: 1 article (01/2013)
4.	Li, Xiang-Long: 1 article (01/2013)
5.	Li, Yang: 1 article (01/2013)
6.	Song, Zhi-Guang: 1 article (01/2013)
7.	Sun, Chao: 1 article (01/2013)
8.	Xiao, Chuan: 1 article (01/2013)
9.	Zhan, Zhuo: 1 article (01/2013)
10.	Zhu, Dan: 1 article (01/2013)

Related Diseases

1.

Neoplasms (Cancer)

01/04/2013 - "JRS-15 exhibited much stronger cytotoxic and pro-apoptotic activity than its parent compound in various cancer cell lines, with IC(50) values in HeLa, HepG2, SK-HEP-1, PC-3M and A549 cells ranging from 12.42 to 28.25 µM. "
01/04/2013 - "Apoptosis is induced in cancer cells via the mitochondrial pathway by the novel xylocydine-derived compound JRS-15."
01/04/2013 - "Taken together, these results indicate that JRS-15 induces cancer cell apoptosis by regulating multiple apoptosis-related proteins, and this compound may therefore be a good candidate reagent for anticancer therapy."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Indicators and Reagents (Reagents)
3.	4- amino- 6- bromo- 7- (xylofuranosyl)pyrrolo(2,3- d)pyrimidine- 5- carboxamide

Related Therapies and Procedures

1.	Therapeutics