FIT-039

11/01/2015 - "Since previous studies demonstrated that FIT-039 exhibited antiviral efficacy without noticeable adverse effects in HSV-1-infected mice, the compound should be further investigated for its clinical potential against HIV-1 infection. "
01/01/2016 - "In this study, we investigated the antiviral effect of FIT-039 on HBV infection. "
01/01/2016 - "These data suggest that CDK9 inhibitor FIT-039 is a promising antiviral candidate for HBV infection."
08/01/2014 - "Specifically, FIT-039 inhibited replication of herpes simplex virus 1 (HSV-1), HSV-2, human adenovirus, and human cytomegalovirus in cultured cells, and topical application of FIT-039 ointment suppressed skin legion formation in a murine HSV-1 infection model. "
01/01/2018 - "The purpose of this study is to assess the therapeutic effect of the newly developed cyclin-dependent kinase 9 (CDK9) inhibitor FIT-039 on cervical neoplasia induced by human papillomavirus (HPV) infection.Experimental"

01/01/2018 - "Thus, FIT-039 is expected to be a novel therapeutic for CIN to prevent cervical cancer. "
01/01/2018 - "FIT-039 also repressed growth of HPV16+, but not HPV- cervical cancer xenografts without any significant adverse effects. "
01/01/2018 - "Finally, the anti-HPV effect of FIT-039 was further examined in vivo, using HPV+ cervical cancer xenografts.Results"
01/01/2018 - " Design: We examined FIT-039 for its effect on HPV gene expression in HPV+ cervical cancer cells. "
01/01/2018 - ": FIT-039 inhibits HPV replication and expression of E6 and E7 viral oncogenes, restoring tumor suppressors p53 and pRb in HPV+ cervical cancer cells. "

01/20/2023 - "Application of the CDK9 inhibitor FIT-039 for the treatment of KSHV-associated malignancy."
01/01/2018 - ": FIT-039 inhibits HPV replication and expression of E6 and E7 viral oncogenes, restoring tumor suppressors p53 and pRb in HPV+ cervical cancer cells. "
01/01/2018 - "CDK9 Inhibitor FIT-039 Suppresses Viral Oncogenes E6 and E7 and Has a Therapeutic Effect on HPV-Induced Neoplasia."
01/01/2019 - "It also inhibited anchorage-independent tumor spheroid growth more effectively than existing chemotherapeutic drugs carboplatin and 5-fluorouracil or the CDK9 inhibitor FIT-039. "
01/01/2018 - "The purpose of this study is to assess the therapeutic effect of the newly developed cyclin-dependent kinase 9 (CDK9) inhibitor FIT-039 on cervical neoplasia induced by human papillomavirus (HPV) infection.Experimental"

01/01/2016 - "The antiviral activity of FIT-039 was prominent at an early phase of viral infection, although the compound did not inhibit preS1-binding to HepG2/NTCP cells. "