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ZCH-2B8a

targeting actin-binding protein coronin-1a, a potential therapeutic agent for B-lineage malignancies

Also Known As:

2B8a antibody; 2B8a mAb; MAb ZCH-2B8a

Networked: 2 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Blood Proteins: 12459
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        ZCH-2B8a: 2
    - Immunoproteins: 43
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        ZCH-2B8a: 2
  - Globulins: 3062
    - Serum Globulins: 553
      - Immunoglobulins: 30480
        Antibodies: 133716
        Monoclonal Antibodies: 56412
        ZCH-2B8a: 2

Experts

1.	Guo, Li: 2 articles (07/2014 - 10/2006)
2.	Tang, Yong-Min: 2 articles (07/2014 - 10/2006)
3.	Wang, Zhu-Jun: 1 article (07/2014)
4.	Xu, Xiao-Jun: 1 article (07/2014)
5.	Zhao, Hai-Zhao: 1 article (07/2014)
6.	Qian, Bai-Qin: 1 article (10/2006)
7.	Shen, Hong-Qiang: 1 article (10/2006)
8.	Yang, Shi-Long: 1 article (10/2006)
9.	Zhang, Hai-Zhong: 1 article (10/2006)
10.	Zhang, Yi: 1 article (10/2006)

Related Diseases

1.	Hematologic Neoplasms (Hematological Malignancy) 07/01/2014 - "MAb ZCH-2B8a (2B8a) was a novel antibody generated in our laboratory, which presented potential to be a therapeutic agent for hematologic malignancies. " 10/01/2006 - "It is concluded that 2B8a antibody primarily reacts to B lineage and monocytic lineage cells which may bear the diagnostic and therapeutic applications among different types of hematopoietic malignancies."
2.	Neoplasms (Cancer) 07/01/2014 - "2B8a mAb is a novel antibody targeting coronin-1a, which has the potential to be a therapeutic agent for B-lineage malignancies." 07/01/2014 - "We investigated the reactivity profile of 2B8a mAb, identified the targeting antigen by proteomic and genetic approaches and evaluated its potential to exert tumor cell killing. " 07/01/2014 - "ZCH-2B8a, an antibody targeting actin-binding protein coronin-1a, is a potential therapeutic agent for B-lineage malignancies." 07/01/2014 - "2B8a antibody was quickly internalized into the target cells once binding to the antigen, but was capable of killing tumor cells through complement dependent cytotoxicity. "
3.	Leukemia 10/01/2006 - "ZCH-2B8a (IgG2a) is a novel monoclonal antibody (McAb) generated in laboratory of Children Hospital of Medical College, Zhejiang University recently using human myeloblastic leukemia cell line KG1a as immunogen. "

Related Drugs and Biologics

1.	Microfilament Proteins (Actin Binding Proteins)
2.	Immunoglobulin G (IgG)
3.	Complement System Proteins (Complement)
4.	Antigens
5.	Monoclonal Antibodies