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SB105-A10

has antiviral activity; structure in first source

Networked: 5 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Peptides: 82426
  - SB105-A10: 5
Macromolecular Substances: 97
- Polymers: 13051
  - Dendrimers: 1702
    - SB105-A10: 5
Therapeutics: 1158551
- Drug Therapy: 293145
  - Drug Delivery Systems
    - Drug Carriers: 2375
      - Dendrimers: 1702
        SB105-A10: 5
Technology, Industry, and Agriculture
- Manufactured Materials
  - Nanostructures
    - Nanoparticles
      - Dendrimers: 1702
        SB105-A10: 5

Experts

1.	Lembo, David: 5 articles (10/2016 - 10/2010)
2.	Bugatti, Antonella: 3 articles (01/2013 - 10/2010)
3.	Landolfo, Santo: 3 articles (01/2013 - 10/2010)
4.	Rusnati, Marco: 3 articles (01/2013 - 10/2010)
5.	Civra, Andrea: 2 articles (10/2012 - 10/2010)
6.	Donalisio, Manuela: 2 articles (10/2012 - 10/2010)
7.	Giuliani, Andrea: 2 articles (10/2012 - 10/2010)
8.	Pirri, Giovanna: 2 articles (10/2012 - 10/2010)
9.	Dutch, Rebecca Ellis: 1 article (10/2016)
10.	Klimyte, Edita M: 1 article (10/2016)

Related Diseases

1.	Virus Diseases (Viral Diseases) 10/01/2010 - "The findings from this study indicate SB105-A10 to be a leading candidate compound for further development as an active ingredient of a topical microbicide against HPV and other sexually transmitted viral infections."
2.	Infections 01/01/2013 - "SB105-A10 inhibited infections by HIV-1 X4 and R5 strains, interfering with the early phases of the viral replication cycle. " 01/01/2013 - "Interestingly, the antiviral activity of SB105-A10 was also detectable in an organ-like structure of human cervicovaginal tissue, in which SB105-A10 inhibited the HIV-1ada R5 strain infection without altering the tissue viability. " 10/15/2016 - "The peptide dendrimer SB105-A10, which binds HS, reduced binding and infection in an F-dependent manner, suggesting that occlusion of HS at the target cell surface is sufficient to prevent infection. " 03/01/2013 - "As such, we were able to inhibit filovirus GP-mediated infection using carrageenan, a broad-spectrum microbicide that mimics heparin, and also using the antiviral dendrimeric peptide SB105-A10, which interacts with heparan sulfate, antagonizing the binding of the virus to cells."
3.	Respiratory Syncytial Virus Infections 10/01/2012 - "SB105-A10 prevented RSV infection when added before the viral inoculum, in line with its proposed HSPG-binding mechanism of action; moreover, antiviral activity was also exhibited when SB105-A10 was added postinfection, as it was able to reduce the cell-to-cell spread of the virus. "

Related Drugs and Biologics

1.	Anti-Infective Agents (Microbicides)
2.	Antiviral Agents (Antivirals)
3.	Peptides (Polypeptides)
4.	Dendrimers (Dendrons)
5.	Heparan Sulfate Proteoglycans (Heparan Sulfate Proteoglycan)
6.	Heparitin Sulfate (Heparan Sulfate)
7.	Heparin (Liquaemin)
8.	Carrageenan