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2,6- dimethoxy- 1,4,5,8- phenanthrenetetrone

has antineoplastic activity; isolated from Dendrobium moniliforme; structure in first source

Also Known As:

moniliformediquinone

Networked: 2 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Organic Chemicals: 133
- Hydrocarbons: 1713
  - Cyclic Hydrocarbons: 97
    - Aromatic Hydrocarbons: 291
      - Polycyclic Aromatic Hydrocarbons: 2020
        Phenanthrenes: 27
        2,6-dimethoxy-1,4,5,8-phenanthrenetetrone: 2
- Quinones: 434
  - 2,6-dimethoxy-1,4,5,8-phenanthrenetetrone: 2
Polycyclic Compounds: 6
- Polycyclic Aromatic Hydrocarbons: 2020
  - Phenanthrenes: 27
    - 2,6-dimethoxy-1,4,5,8-phenanthrenetetrone: 2

Experts

1.	Lee, Yean-Jang: 2 articles (01/2016 - 05/2014)
2.	Chen, Zi-Hui: 1 article (01/2016)
3.	Kuo, Hsing-Chun: 1 article (01/2016)
4.	Lee, Kam-Fai: 1 article (01/2016)
5.	Lin, Wea-Lung: 1 article (01/2016)
6.	Shen, Chien-Heng: 1 article (01/2016)
7.	Shie, Ming-Shiun: 1 article (01/2016)
8.	Tseng, Tsui-Hwa: 1 article (01/2016)
9.	Dong, Yu-Shun: 1 article (05/2014)
10.	Guh, Jih-Hwa: 1 article (05/2014)

Related Diseases

1.	Weight Loss (Weight Reduction) 05/01/2014 - "The in vivo study revealed that moniliformediquinone completely inhibited tumor growth with no weight loss. "
2.	Neoplasms (Cancer) 05/01/2014 - "The in vivo study revealed that moniliformediquinone completely inhibited tumor growth with no weight loss. "
3.	Prostatic Neoplasms (Prostate Cancer) 05/01/2014 - "Moniliformediquinone induced cell cycle arrest at the S-phase and subsequent apoptosis in the hormone refractory metastatic prostate cancer cell lines PC-3 and DU-145. " 05/01/2014 - "Several pharmacological and biochemical assays were used to characterize the apoptotic signaling pathways of moniliformediquinone, a natural product, in hormone refractory metastatic prostate cancer. " 05/01/2014 - "Moniliformediquinone induces in vitro and in vivo antitumor activity through glutathione involved DNA damage response and mitochondrial stress in human hormone refractory prostate cancer." 05/01/2014 - "Our data suggest that moniliformediquinone is a potential anticancer agent for hormone refractory metastatic prostate cancer by decreasing cellular glutathione, leading to a DNA damage response and cell cycle arrest at the S-phase. "
4.	Liver Cirrhosis (Hepatic Cirrhosis) 01/01/2016 - "Moniliformediquinone as a potential therapeutic agent, inactivation of hepatic stellate cell and inhibition of liver fibrosis in vivo."

Related Drugs and Biologics

1.	A-Form DNA (A-DNA)
2.	Hormones (Hormone)
3.	Glutathione (Reduced Glutathione)
4.	Antineoplastic Agents (Antineoplastics)