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1- methyl- 7- nitro- 4- (5- (piperidin- 1- yl)pentyl)- 3,4- dihydroquinoxalin- 2(1H)- one

has antitrichonomal activity; structure in first source

Also Known As:

VAM2-6

Networked: 2 relevant articles (2 outcomes, 0 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Piperidines: 17
    - 1-methyl-7-nitro-4-(5-(piperidin-1-yl)pentyl)-3,4-dihydroquinoxalin-2(1H)-one: 2
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Quinoxalines: 324
      - 1-methyl-7-nitro-4-(5-(piperidin-1-yl)pentyl)-3,4-dihydroquinoxalin-2(1H)-one: 2

Experts

1.	Arán, Vicente J: 2 articles (12/2013 - 04/2013)
2.	Malagón, Filiberto: 2 articles (12/2013 - 04/2013)
3.	Rivera, Norma: 2 articles (12/2013 - 04/2013)
4.	Fortoul, Teresa I: 1 article (12/2013)
5.	Marrero-Ponce, Yovani: 1 article (12/2013)
6.	Rivera, Ernesto: 1 article (12/2013)
7.	Rojas, Marcela: 1 article (12/2013)
8.	Zepeda, Armando: 1 article (12/2013)
9.	Martínez, Cecilia: 1 article (04/2013)
10.	Ponce, Yovani Marrero: 1 article (04/2013)

Related Diseases

1.	Parasitemia 04/01/2013 - "A 4-day dosage of 20 mg/kg of VAM2-6 showed a 97% chemosuppression of total parasitemia on the fifth day, a 28 days survival time, and 20% of cured animals. "
2.	Trichomonas Infections 12/01/2013 - "The compound VAM2-6 (1-methyl-7-nitro-4-(5-(piperidin-1-yl)pentyl)-3,4-dihydroquinoxalin-2(1H)-one) has previously been shown to have an in vitro efficacy of 100% at a concentration of 100 µg ml(-1) against Trichomonas vaginalis, a protozoon parasite that causes the sexually transmitted disease trichomoniasis. "
3.	Sexually Transmitted Diseases (Sexually Transmitted Disease) 12/01/2013 - "The compound VAM2-6 (1-methyl-7-nitro-4-(5-(piperidin-1-yl)pentyl)-3,4-dihydroquinoxalin-2(1H)-one) has previously been shown to have an in vitro efficacy of 100% at a concentration of 100 µg ml(-1) against Trichomonas vaginalis, a protozoon parasite that causes the sexually transmitted disease trichomoniasis. "
4.	Infections 04/01/2013 - "Compound 1-methyl-7-nitro-4-(5-(piperidin-1-yl)pentyl)-3,4-dihydroquinoxalin-2(1H)-one (VAM2-6) was evaluated against a blood-induced infection with chloroquine-sensitive Plasmodium yoelii yoelii lethal strain in CD1 mice in a 4-day test scheme. "

Related Drugs and Biologics

1.	Chloroquine (Aralen)