Hydroxymethyl and Formyl Transferases

Enzymes that catalyze the transfer of hydroxymethyl or formyl groups. EC 2.1.2.

Also Known As:

Formyl Transferases; Formyltransferases; Hydroxymethyl Transferases; Hydroxymethyltransferases; Transformylase; Transformylases; Transhydroxymethylases; Transferase, Formyl; Transferase, Hydroxymethyl; Transferases, Formyl; Transferases, Hydroxymethyl; Formyl Transferase; Formyltransferase; Hydroxymethyl Transferase; Hydroxymethyl and Formyl Transferase; Hydroxymethyltransferase; Transhydroxymethylase

Networked: 93 relevant articles (4 outcomes, 14 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - One-Carbon Group Transferases
      - Hydroxymethyl and Formyl Transferases: 93
        Glycine Hydroxymethyltransferase: 139
        Phosphoribosylglycinamide Formyltransferase: 21
        Aminomethyltransferase: 12
        Phosphoribosylaminoimidazolecarboxamide Formyltransferase: 9
        deoxycytidylate hydroxymethyltransferase: 4
        Glutamate Formimidoyltransferase: 3
        inosine monophosphate synthase: 2
        methionyl-tRNA formyltransferase: 2
        3-methyl-2-oxobutanoate hydroxymethyltransferase: 1
        dUMP-hydroxymethylase: 1
        6-hydroxymethylbenzo(alpha)pyrene synthetase
        AICAR Transformylase Inosine Monophosphate Cyclohydrolase Deficiency
        benzopyrene hydroxymethylase
        deoxyhydroxymethylcytosine hydroxymethylase
        E coli purT protein
        formylmethanofuran-tetrahydromethanopterin formyltransferase
        human FTCDNL1 protein
        mouse Shmt2 protein
        S cerevisiae DIT1 protein

Experts

1.	Gangjee, Aleem: 8 articles (02/2024 - 10/2011)
2.	Hou, Zhanjun: 8 articles (02/2024 - 10/2011)
3.	Matherly, Larry H: 8 articles (02/2024 - 10/2011)
4.	Dann, Charles E: 4 articles (02/2024 - 01/2016)
5.	O'Connor, Carrie: 4 articles (02/2024 - 01/2018)
6.	Wallace-Povirk, Adrianne: 4 articles (02/2024 - 01/2018)
7.	Kim, Seongho: 3 articles (02/2024 - 01/2020)
8.	Polin, Lisa: 3 articles (02/2024 - 10/2011)
9.	Bao, Xun: 2 articles (02/2024 - 01/2021)
10.	Dekhne, Aamod S: 2 articles (02/2024 - 01/2020)

Related Diseases

1.	Neuroblastoma 01/15/2009 - "In this study, the effect of increased MTHFS expression on the efficacy of the glycinamide ribonucleotide formyltransferase (GARFT) inhibitor LY309887 was investigated in SH-SY5Y neuroblastoma. "
2.	Colorectal Neoplasms (Colorectal Cancer) 01/01/2006 - "Pharmacogenomic studies on the role of polymorphism of the serine-hydroxymethyl-transferase (SHMT) gene in the efficacy of 5-FU and FOLFIRI protocols of colorectal cancer patients revealed a significant effect resulting in altered overall survival as well." 01/01/2017 - "In the present investigation we found that expression of three mitochondrial folate metabolic enzymes, serine hydroxymethyl transferase (SHMT2), methylenetetrahydrofolate dehydrogenase (MTHFD2) and aldehyde dehydrogenase 1 family member L2 (ALDH1L2), were upregulated in human colorectal tumor tissues compared to normal tissues. " 03/01/2007 - "Recently, the novel antifolates raltitrexed and pemetrexed that target thymidylate synthase (TS) and glycineamide ribonucleotide transformylase (GARTF) were introduced for the treatment of colorectal cancer and malignant pleural mesothelioma. "
3.	Juvenile Arthritis (Juvenile Idiopathic Arthritis) 08/01/2011 - "Association of the 5-aminoimidazole-4-carboxamide ribonucleotide transformylase gene with response to methotrexate in juvenile idiopathic arthritis." 04/01/2015 - "5-Aminoimidazole-4-carboxamide ribonucleotide-transformylase and inosine-triphosphate-pyrophosphatase genes variants predict remission rate during methotrexate therapy in patients with juvenile idiopathic arthritis."
4.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 10/01/2012 - "Association between expression of thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide formyltransferase and efficacy of pemetrexed in advanced non-small cell lung cancer."
5.	Neoplasms (Cancer) 01/01/2018 - "Depletion of ATIC or inhibition of its transformylase activity significantly reduced the surviving fraction of cells in clonogenic survival assays in multiple cancer cell lines. " 04/01/2010 - "We used an immunofluorescence-based automated quantitative technique to score RRM1, ERCC1, TS, and Topo2alpha levels in tumor specimens from 100 patients with SCLC and immunohistochemistry to semiquantitatively score levels of TS, 5-phosphoribosyl-glycinamide formyl-transferase, and folyl-polyglutamate synthase expression. " 01/01/2017 - "Systematic knockdown of all six genes using short hairpin RNAs (shRNAs) and follow-up functional studies demonstrated that serine hydroxymethyl transferase 1 (SHMT1) was necessary for ovarian cancer tumor growth and cell migration in culture and tumor formation in mice. " 01/01/2020 - "The TET2 DNA hydroxymethyltransferase is frequently disrupted by somatic mutations in diffuse large B cell lymphomas (DLBCLs), a tumor that originates from germinal center (GC) B cells. " 01/04/2024 - "Serine hydroxymethyl transferase 2 (SHMT2) is one of the most frequently expressed metabolic enzymes in human malignancies. "

Related Drugs and Biologics

1.	glycinamide ribonucleotide
2.	Serine (L-Serine)
3.	Methotrexate (Mexate)
4.	Pemetrexed (MTA)
5.	Ribonucleotides
6.	thymidylate synthase-dihydrofolate reductase
7.	6R- 2',5'- thienyl- 5,10- dideazatetrahydrofolic acid
8.	Fluorouracil (Carac)
9.	Pyrophosphatases
10.	Inosine Triphosphate (ITP)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Radiotherapy