Interleukin-10 (Interleukin 10)

A cytokine produced by a variety of cell types, including T-LYMPHOCYTES; MONOCYTES; DENDRITIC CELLS; and EPITHELIAL CELLS that exerts a variety of effects on immunoregulation and INFLAMMATION. Interleukin-10 combines with itself to form a homodimeric molecule that is the biologically active form of the protein.

Also Known As:

Networked: 22330 relevant articles (1004 outcomes, 2735 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Liu, Yang: 47 articles (01/2024 - 08/2013)
2.	Zhang, Yan: 40 articles (05/2024 - 01/2010)
3.	Li, Jing: 39 articles (02/2024 - 08/2004)
4.	Zhang, Wei: 36 articles (08/2023 - 02/2009)
5.	Zhang, Li: 33 articles (03/2024 - 11/2003)
6.	Wang, Yan: 33 articles (12/2023 - 02/2002)
7.	Wang, Wei: 31 articles (03/2024 - 11/2003)
8.	Chen, Wei: 29 articles (04/2024 - 02/2007)
9.	Flavell, Richard A: 29 articles (02/2024 - 02/2006)
10.	Zhang, Jian: 29 articles (05/2023 - 01/2003)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2016 - "Acute inflammation and Th1 response are important in the early clearance of the bacteria as it was emphasized by the association between immune genes (i.e.: HLA, IFNG, TNF, NRPAM1, IL10) variants and the development of active pulmonary TB. " 04/01/1998 - "Treatment with IL-10 resulted in a marked improvement in intestinal inflammation. " 01/01/2019 - "These results show that PTPN22 promotes intestinal inflammation in IL-10-deficient mice, suggesting that therapeutic targeting of PTPN22 might be beneficial in patients with IBD and mutations in IL-10 and IL-10R." 10/01/1999 - "In conclusion, reducing the inflammatory response to SCI by systemic administration of IL-10 resulted in a significant reduction in neuronal damage, suggesting that targeting injury-induced inflammation may be an effective treatment strategy for acute SCI." 01/01/2020 - "The therapeutic efficacy of anti-TNF in resolving intestinal inflammation is critically dependent on IL-10 signalling in macrophages."
2.	Infections 01/01/2018 - "Underlying pathways for those genes located in the respective QTL for resistance to primary infection and protection against heterologous challenge were related mainly to immune response, with IL-10 signaling in the backcross primary infection being the most significant. " 02/01/2012 - "Although Foxp3(+) regulatory CD4(+) T cells produce IL-10 during infection, highly activated IFN-γ(+) Th1 cells were shown to be the essential and sufficient source of IL-10 to guarantee protection against severe immune-mediated pathology. " 01/01/2021 - "Heterogeneity and mean expression of IFN-γ, IL-10 and TNF-α did not differ significantly over time, however, expression of TGF-β at 90 days was significantly greater than that seen at 30 days after infection." 10/31/2017 - "donovani infection using a CCR2 antagonist reduces the frequency of the pathogenic IFN-γ/IL10 dual producer CD4+ T cells in the spleen and leads to a significant reduction in parasite loads in the liver and spleen. " 09/15/2011 - "Ab4 infection resulted in a significant reduction of IL-10 responses in adult horses. "
3.	Colitis 10/27/2010 - "The aim of this study was to determine if administration of cis-UCA would be effective in attenuating colitis and the possible role of IL-10. " 08/01/2004 - "This study investigates the therapeutic efficacy of an adenovirus encoding IL-10 (AdvmuIL-10) in the treatment of experimental colitis. " 12/01/2002 - "This study investigates the therapeutic efficacy of an adenoviral vector encoding IL-10 (AdvmuIL-10) in experimental colitis. " 02/01/2009 - "We hypothesized that interleukin-10 delivery to the distal gastrointestinal tract using a unique delivery vehicle may serve as a novel therapeutic for the treatment of experimental colitis. " 12/01/2006 - "Intragastric administration of Lactococcus lactis genetically modified to secrete IL-10 in situ in the intestine was shown to be effective in healing and preventing chronic colitis in mice. "
4.	Neoplasms (Cancer) 03/16/2021 - "Conversely, the PTX-induced upregulation of the M2 marker gene, Il10 in CD11b+ myeloid cells from 4T1 tumor-bearing mice treated was dramatically reduced by the administration of the HO-1 inhibitor. " 12/01/2015 - "In this study, we provided evidence that MSCs derived from cervical tumors (CeCa-MSCs) cocultured with CeCa cells induced significant expression of TGF-β1 and secretion of IL-10 by CeCa cells compared to MSCs derived from the normal cervix (NCx-MSCs) and normal bone marrow (BM-MSCs; gold standard). " 10/01/2021 - "Importantly, antibody-mediated IL-10 ablation in vivo improved effector cell functions and significantly suppressed tumor development. " 01/01/2006 - "In conclusion, a high IL-10 gene expression in the recipient MNCs may be related to a reduced incidence of acute GVHD grades II to IV and a reduced graft-versus-tumor effect after HCT with nonmyeloablative conditioning." 01/10/2017 - "Interestingly, vaccination combined with simultaneous blockade of IL-10 and PD-L1 induced stronger immune responses, resulting in a higher therapeutic efficacy in tumor-bearing mice. "
5.	Necrosis 06/18/2008 - "The two fractions caused a significant reduction in production of tissue necrosis factor-alpha and an increase in interleukin 10 (IL-10)." 10/01/2003 - "Interleukin 10 gene transfection of donor lungs ameliorates posttransplant cell death by a switch from cellular necrosis to apoptosis." 09/01/2021 - "This study analysed the plasma levels of IL (interleukin)-6, IL-1β, IL-10, tumour necrosis factor (TNF)-α, 4‑hydroxy-2-nonenal (4-HNE) and 8-hydroxy-2'deoxyguanosine (8-OHdG) in children enrolled in the HXT+VitE trial (ClinicalTrials.gov, NCT02842567). " 10/01/2004 - "In this study, we investigated whether strain CR1 caused apoptosis or necrosis of macrophages after its inoculation into mice peritoneal cavity, and whether this correlated with the secretion of IL-10. " 09/15/2003 - "In this study, we show that IL-10 knockout mice infected with this parasite develop extensive areas of coagulative necrosis in the liver, and newborn larvae are required for lesion formation. "

Related Drugs and Biologics

1.	Cytokines
2.	Interleukin-6 (Interleukin 6)
3.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
4.	Interleukin-4 (Interleukin 4)
5.	Interleukins
6.	Messenger RNA (mRNA)
7.	Interleukin-8 (Interleukin 8)
8.	Interferons
9.	Interleukin-12 (IL 12)
10.	Interleukin-17 (Interleukin 17)

Related Therapies and Procedures

1.	Therapeutics
2.	Aftercare (After-Treatment)
3.	Transplantation
4.	Immunotherapy
5.	Drug Therapy (Chemotherapy)