Tuberculin (PPD)

A protein extracted from boiled culture of tubercle bacilli (MYCOBACTERIUM TUBERCULOSIS). It is used in the tuberculin skin test (TUBERCULIN TEST) for the diagnosis of tuberculosis infection in asymptomatic persons.

Also Known As:

Networked: 12277 relevant articles (363 outcomes, 1401 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Meltzer-Brody, Samantha: 37 articles (02/2024 - 05/2009)
2.	Lalvani, Ajit: 29 articles (01/2020 - 11/2002)
3.	Salvi, Giovanni E: 24 articles (10/2023 - 06/2002)
4.	Andersen, Peter: 24 articles (01/2020 - 04/2003)
5.	Van Lieshout, Ryan J: 22 articles (01/2024 - 10/2011)
6.	Sculean, Anton: 22 articles (10/2023 - 07/2004)
7.	Boom, W Henry: 20 articles (04/2024 - 01/2008)
8.	Lang, Niklaus P: 20 articles (02/2021 - 04/2002)
9.	Bezos, Javier: 19 articles (02/2024 - 07/2006)
10.	Stein, Catherine M: 18 articles (04/2024 - 01/2008)

Related Diseases

1.	Tuberculosis (Tuberculoses) 01/01/2019 - "It is known to be most effective in preventing tuberculosis in patients with positive tuberculin skin test. " 02/01/2005 - "tuberculosis in most tuberculin skin-test-negative adults at week 8, suggesting the immunological efficacy of vaccination." 09/01/2003 - "Monetary incentives are highly effective in increasing adherence to referral for screening CXRs to exclude active tuberculosis after syringe exchange-based tuberculin skin testing. " 01/01/2010 - "It has a high sensitivity since it produces a positive result in virtually all patients with tuberculosis, and during an active tuberculous process, the positive results of the positive diaskintest are higher than those of the tuberculin skin test, which allows the diaskintest to be used for the determination of the activity of the process. " 07/01/2007 - "Until recently the tuberculin skin test was the only available method for diagnosing tuberculosis, however it suffers several methodological weaknesses: high rate of false positive results in vaccinated populations, the subjectivity of the evaluation and the booster effect. "
2.	Infections 01/01/2019 - "Comparing to tuberculin skin test (TST) they lack false positive results in the populations vaccinated with BCG, and in most non-tuberculous mycobacteria (NTM) infections. " 01/01/2019 - "Comparing to tuberculin skin test (TST) they lack false positive results in the populations vaccinated with BCG, and in most non-tuberculous mycobacteria (NTM) infections. " 10/01/2005 - "The tuberculin skin test (TST) is inaccurate because of the high incidence of anergy in skin testing in HD patients and its inability to differentiate latent from eradicated TB infection. " 01/01/2002 - "The strong positive reaction of calves to tuberculin inoculation 15 weeks post vaccination showed the capability of BCG in causing the release of IFN-gamma in the peripheral blood, indicating its role in protection against infection with Mycobacterium bovis in calves." 01/21/2017 - "This report describes how Mycobacterium bovis infection was controlled and eventually eradicated in a farmed red deer herd in the north of England, following sustained tuberculin skin testing supplemented with serological (antibody) tests over a period of approximately two years. "
3.	Hemorrhage 06/01/2024 - "The ratio of probing pocket depth (PPD) ≥4 mm, bleeding on probing (BOP), full-mouth plaque control record (PCR), periodontal epithelial surface area (PESA) and periodontal inflamed surface area (PISA) also significantly improved. " 11/01/2018 - "A statistically significant reduction was observed in PI, sulcus bleeding index, PPD, and RAL at 1 and 3 months in all the three groups. " 01/01/2017 - "Results: Both groups showed statistically significant improvements in terms of bleeding on probing (P < 0.001), probing pocket depth (PPD) (P = 0.006) and modified plaque index (P < 0.001), with no significant differences between the 2 groups (P > 0.05). " 03/01/2016 - "Baseline data were compared at the end, i.e., 90(th) day a significant reduction in plaque scores, gingival bleeding, and PPD was observed however no significant gain in the clinical attachment was observed. " 12/01/2014 - "Bleeding on probing (BOP), probing pocket depth (PPD), and clinical attachment level (CAL) were recorded at baseline, 4 wk and 12 wk. Significant reduction in BOP scores was observed in both the groups at 12weeks (p<0.001). "
4.	Warts (Wart) 07/01/2019 - "Complete remission was more (P = 0.539, Fischer's exact test) in the Mw group (68.8%) than the PPD group (50%); and was significantly higher (P = 0.049, Mann-Whitney test) in patients having shorter duration of warts. " 04/01/2021 - "Both IL PPD and Vit.D3 injection are safe and effective for treatment of plantar warts even recalcitrant or multiple, with no postprocedural downtime, better results, and patient satisfaction. " 01/01/2021 - "We have assessed efficacy of intralesional tuberculin in patients with verruca vulgaris and to see the long term follow-up at 12 months. " 01/01/2024 - "Original studies on treating cutaneous or anogenital warts with PPD were included. " 01/01/2016 - "To study the effect of PPD in the treatment of warts. "
5.	Periodontitis 03/01/2021 - "Results revealed that when patients from all studies were categorized based on their baseline CAL, AB demonstrated significant benefits over RaPDT in the improvement of PPD [weighted mean differences (WMD) = -0.36, 95% confidence interval (CI) = -0.71 to -0.02, p < 0.05] in the patients with severe periodontitis (CAL baseline ≥5 mm) 3-month postoperatively, and CAL (WMD = -0.57, 95% CI = -1.11 to -0.04, p < 0.05) at 6-month observation. " 04/26/2024 - "The periodontitis group showed statistically significant correlations between salivary PLGF levels, BoP(p = 0.005) and PPD(p = 0.005), and significant correlations of PLGF with PPD (p = 0.035) for both groups. " 04/01/2022 - "Significant reduction in GBI, PPD and gingival MPO activity and ABH was seen in animals treated with LPPp compared with periodontitis. " 11/07/2019 - "The association between initial clinical parameters and significant clinical improvement, including the reductions of probing pocket depth (PPD) and clinical attachment loss (CAL), in molar teeth with severe periodontitis after NSPT was assessed by a generalized linear model and logistic regression. " 01/01/2015 - "The extent of periodontitis, as measured by the percent of teeth with CAL ≥3 mm and the percent of teeth with PPD ≥3 mm, was also significantly greater among patients with MetS (P < 0.005). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Antigens
3.	Interferon-gamma (Interferon, gamma)
4.	Tuberculin (PPD)
5.	Isoniazid (Ftivazide)
6.	brexanolone
7.	Anti-Bacterial Agents (Antibiotics)
8.	Gold
9.	Interferons
10.	Vaccines

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Aftercare (After-Treatment)
4.	Drug Therapy (Chemotherapy)
5.	Debridement