Gold

A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.

Networked: 16763 relevant articles (667 outcomes, 2189 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shi, Xiangyang: 65 articles (03/2023 - 07/2007)
2.	Vestbo, Jørgen: 49 articles (02/2024 - 08/2002)
3.	Silverman, Edwin K: 48 articles (10/2023 - 02/2010)
4.	Han, MeiLan K: 45 articles (05/2024 - 12/2009)
5.	El-Sayed, Mostafa A: 43 articles (09/2020 - 05/2005)
6.	Vogelmeier, Claus F: 42 articles (03/2024 - 03/2013)
7.	Shen, Mingwu: 39 articles (01/2023 - 11/2009)
8.	Martinez, Fernando J: 38 articles (03/2024 - 12/2009)
9.	Crapo, James D: 37 articles (11/2023 - 02/2010)
10.	Wang, Jing: 37 articles (06/2023 - 02/2008)

Related Diseases

1.	Neoplasms (Cancer) 07/11/2014 - "The significant improvement in sensitivity illustrates that combining gold nanoparticles with the on-site fabricated aligned MWCNT array represents a promising platform for achieving sensitive biosensor for fast mutation screening related to most human cancer types. " 06/15/2022 - "Herein, we demonstrate that subtle structural modifications of the phosphaphenalene-based gold(I) complexes lead to modify their electronic distribution, endow them with marked photophysical properties and enhance their efficacy against cancer. " 01/01/2021 - "Hybrid nanomaterials as a formulation of anticancer drugs with gold nanoparticles (AuNPs) have adequately proven efficacious in controlled release as well as disintegration into ultrasmall nanoparticles dragging the drug to penetrate deep into tumor tissues and consequently getting cleared from the body. " 01/08/2013 - "Statistically significant reduction of gold accumulation was observed in acidic tumors and kidney when pH-insensitive K-pHLIP was used as a vehicle, suggesting an important role of pH in the pHLIP-mediated targeting of gold nanoparticles. " 07/12/2019 - "A detailed pharmacokinetic study showed a time-dependent accumulation of gold nanoshells within the tumors, significantly greater with functionalized gold nanoshells at 72 h. "
2.	Chronic Obstructive Pulmonary Disease (COPD) 01/01/2009 - "The NNT in the overall study group was 2; the same NNT was obtained in GOLD stages 2, 3, and 4, but was 8 in stage 1. PR is highly effective in improving the exercise capacity of patients with COPD, as demonstrated by a valuable NNT, with better results in patients with a more severe disease." 07/01/2014 - "The %WA fifth to first of 1.51 (sensitivity, 83%; specificity, 89%) was best for diagnosis of GOLD 3-4. Ratios of peripheral-to-central airway LA and %WA show improved correlation with COPD severity." 03/01/2005 - "The Global Initiative for Chronic Obstructive Lung Disease (GOLD) underlines that spirometry is the gold standard as the most reproducible, standardised, and objective way of measuring airflow limitation in the diagnosis and assessment of Chronic Obstructive Pulmonary Disease (COPD). " 01/01/2020 - "GFF MDI significantly improved lung function versus monocomponents and placebo MDI in GOLD category A patients with moderate-to-very severe COPD, with no unexpected safety findings." 05/01/2018 - "The Global Initiative for Chronic Obstructive Lung Disease (GOLD) guidelines are the international gold standard, and it is important to understand how these are being applied in general practice. "
3.	Rheumatoid Arthritis 07/01/1986 - "Although gold is one of the few therapeutic agents that has been proven effective in producing remission in patients with rheumatoid arthritis, its mechanism of action is unknown. " 03/14/2011 - "Gold(I)-based drugs have been used successfully for the treatment of rheumatoid arthritis (RA) for several years. " 04/03/1987 - "Although certain gold [Au(I)] compounds have been used effectively in the treatment of rheumatoid arthritis for some years, the molecular basis for such therapeutic action has been unclear. " 07/01/1998 - "Clinical remission in rheumatoid arthritis: efficacy of a second course of intra-muscular gold." 02/01/1998 - "Improved functional outcome in patients with early rheumatoid arthritis treated with intramuscular gold: results of a five year prospective study."
4.	Breast Neoplasms (Breast Cancer) 01/01/2020 - "The aim of this paper was to develop a gold-based compound with an efficient therapeutic potential against breast cancer. " 10/06/2023 - "The current work aimed to evaluate the efficacy of a specific combination of gold nanoparticles (GNPs) and Newcastle disease virus (NDV) to enhance the antitumor effect of breast cancer in both in vitro and in vivo models. " 01/01/2023 - "Hence, in the present study, we conjugated polyherbal formulation with gold nanoparticles and studied its effect on inducing ferroptosis in drug-resistant breast cancer cell lines. " 01/01/2022 - "In this study, we investigated the maximum detection depth through which the retrieval of SERS signal of a passively targeted biphenyl-4-thiol tagged gold nanoparticle (NP) imaging agent, injected subcutaneously into a mouse bearing breast cancer tumour, was possible. " 01/01/2022 - "Gold-nanoparticle-enriched breast tissue in breast cancer treatment using the INTRABEAM® system: a Monte Carlo study."
5.	Tuberculosis (Tuberculoses) 01/01/2018 - "Among high risk healthcare workers in a low prevalence tuberculosis setting, the Gold Plus assay had a higher proportion of positive results than the Gold in-tube assay. " 04/22/2006 - "Overall, T-SPOT.TB produced significantly more positive results (38%, n=144, vs 26%, n=100, with QuantiFERON-TB Gold; p<0.0001), and close contacts of patients with active tuberculosis were more likely to be positive with T-SPOT.TB than with QuantiFERON-TB Gold (p=0.0010). " 09/01/2005 - "In 11 patients with active tuberculosis (5 culture-confirmed), QFT-Gold provided more positive results than the TST (66.7% vs. 33.3%; p = 0.165). " 09/01/2011 - "Among positive QuantiFERON-TB Gold patients, 25 received a full anti-tuberculosis treatment, which was effective in 15 cases (60%). " 10/01/2014 - "This article provides a detailed analysis of the origins and significance of the 1926 clinical trial of Sanocrysin, a gold compound thought at the time to be useful in the treatment of tuberculosis. "

Related Drugs and Biologics

1.	Salts
2.	Auranofin (Ridaura)
3.	Doxorubicin (Adriamycin)
4.	Silver
5.	Silicon Dioxide (Silica)
6.	Folic Acid (Vitamin M)
7.	Peptides (Polypeptides)
8.	1-phenyl-3,3-dimethyltriazene (PDT)
9.	Proteins (Proteins, Gene)
10.	Methotrexate (Mexate)

Related Therapies and Procedures

1.	Therapeutics
2.	Photothermal Therapy
3.	Radiotherapy
4.	Drug Therapy (Chemotherapy)
5.	Lasers (Laser)