Pentoxifylline (Trental)

A METHYLXANTHINE derivative that inhibits phosphodiesterase and affects blood rheology. It improves blood flow by increasing erythrocyte and leukocyte flexibility. It also inhibits platelet aggregation. Pentoxifylline modulates immunologic activity by stimulating cytokine production.

Also Known As:

Networked: 2611 relevant articles (383 outcomes, 655 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Coimbra, Raul: 18 articles (06/2010 - 11/2003)
2.	Bravo-Cuellar, Alejandro: 12 articles (02/2024 - 03/2006)
3.	Tsai, Tun-Jun: 12 articles (11/2017 - 12/2002)
4.	Gude, Rajiv P: 12 articles (03/2014 - 08/2003)
5.	Chen, Yung-Ming: 11 articles (12/2021 - 12/2002)
6.	Chiang, Wen-Chih: 11 articles (12/2021 - 12/2002)
7.	Belcaro, G: 11 articles (01/2002 - 01/2002)
8.	Cesarone, M R: 11 articles (01/2002 - 01/2002)
9.	De Sanctis, M T: 11 articles (01/2002 - 01/2002)
10.	Geroulakos, G: 11 articles (01/2002 - 01/2002)

Related Diseases

1.	Intermittent Claudication 07/01/1988 - "Pentoxifylline, recently approved for the treatment of intermittent claudication, is hepatically cleared with a high degree of first-pass metabolism. " 01/01/1983 - "The positive results derived from pentoxifylline treatment are significant because, for the first time, treadmill testing can prove the effectiveness of a hemorheologic drug, such as pentoxifylline, in the treatment of patients with intermittent claudication. " 09/01/1989 - "In summary, pentoxifylline improved function and symptoms in 13 of 22 geriatric patients with intermittent claudication; the drug was safe and well tolerated at the usual dosage in this geriatric patient population." 01/01/2002 - "The efficacy of pentoxifylline (PXF) in severe intermittent claudication was studied comparing PXF and placebo. " 07/15/1990 - "To review the evidence for efficacy of three contemporary treatments for intermittent claudication: pentoxifylline, exercise programs, and smoking cessation. "
2.	Alcoholic Hepatitis 06/14/2016 - "Is pentoxifylline effective in alcoholic hepatitis? " 11/01/2016 - "The evidence from this study is insufficient to support any recommendations regarding the mortality benefit of pentoxifylline in severe alcoholic hepatitis." 08/19/2013 - "Group D: pentoxifylline / prednisoloneThe trial aims to randomise 1,200 patients with severe alcoholic hepatitis, in order to provide sufficient power to determine whether either of the two interventions is effective. " 05/01/2013 - "Pentoxifylline in severe alcoholic hepatitis: a prospective, randomised trial." 05/01/2012 - "Pentoxifylline in severe alcoholic hepatitis: a prospective, randomised trial."
3.	Fibrosis (Cirrhosis) 11/01/2000 - "A statistically significant reduction of fibrosis was obtained with pentoxifylline when administered intraperitoneally rather than intravenously. " 08/01/2014 - "Efficacy of pentoxifylline as an antifibrotic drug in experimental murine schistosomal hepatic fibrosis." 11/01/2020 - "The aim of the study was to evaluate the effectiveness of seagull-shaped nasolabial flap (NLF) along with adjunctive short-term oral pentoxifylline in the surgical reconstruction of oral sub mucous fibrosis (OSMF) following fibrotomy. " 01/01/2017 - "Recently, the effectiveness of pentoxifylline in the treatment of fibrosis via attenuating and reversing fibrotic lesions has been demonstrated in several clinical trials and animal studies. " 03/14/2016 - "Our study is the first to present evidence of experimental epidural fibrosis prevention with pentoxifylline."
4.	Neoplasms (Cancer) 11/01/2003 - "Surprisingly, our study revealed that pentoxifylline significantly promoted C-26-derived metastatic tumor growth in liver. " 11/01/2003 - "Moreover, some beneficial properties of pentoxifylline, which could be useful in cancer treatment, have been reported and a few clinical trials with oncological patients have been performed. " 11/01/2003 - "Therefore, the aim of the present study was to evaluate the influence of pentoxifylline on tumor development. " 10/01/2001 - "In this study we investigated the effect of pentoxifylline (PTX) on tumor-induced neovascularization as well as on different steps involved in the angiogenic process. " 09/01/1993 - "[An experimental study of the possibilities of using pentoxifylline for the prevention of cancer at different sites]."
5.	Sepsis (Septicemia) 08/01/1996 - "In contrast, no significant reduction in nitroglycerine-induced vascular relaxation was seen in rats with sepsis irrespective of pentoxifylline treatment. " 08/01/1992 - "Recent evidence suggests that pentoxifylline (PTX) may be useful in the treatment of sepsis. " 11/18/2021 - "Protocol: Pentoxifylline optimal dose finding trial in preterm neonates with suspected late onset sepsis (PTX-trial)." 10/05/2011 - "In four randomised controlled trials, 227 neonates with suspected or confirmed sepsis were randomised to pentoxifylline or placebo. " 10/01/2010 - "Given the substantial burden of sepsis, NEC, and CLD in high-risk preterm neonates, and the findings of this systematic review, pentoxifylline needs to be evaluated urgently as a preventative and therapeutic agent for these conditions in randomized controlled trials that can detect minimal clinically significant effect sizes. "

Related Drugs and Biologics

1.	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)
2.	Adrenal Cortex Hormones (Corticosteroids)
3.	Pentoxifylline (Trental)
4.	Cytokines
5.	Vitamin E
6.	Tocopherols (Tocopherol)
7.	Prednisolone (Predate)
8.	Antioxidants
9.	Cilostazol (Pletal)
10.	Steroids

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Conservative Treatment
4.	Resuscitation
5.	Drug Therapy (Chemotherapy)