Penicillamine (Cuprimine)

3-Mercapto-D-valine. The most characteristic degradation product of the penicillin antibiotics. It is used as an antirheumatic and as a chelating agent in Wilson's disease.

Also Known As:

Cuprimine; D-Penicillamine; Copper Penicillaminate; Cuprenil; D-3-Mercaptovaline; Metalcaptase; D 3 Mercaptovaline; D Penicillamine; Penicillaminate, Copper; beta,beta Dimethylcysteine; Dimethylcysteine; Mercaptovaline; beta,beta-Dimethylcysteine; D-Valine, 3-mercapto-

Networked: 2713 relevant articles (153 outcomes, 244 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Członkowska, Anna: 7 articles (08/2023 - 02/2014)
2.	Litwin, Tomasz: 7 articles (08/2023 - 02/2014)
3.	Clements, P J: 6 articles (10/2006 - 11/2000)
4.	Mumper, Russell J: 5 articles (06/2010 - 02/2005)
5.	Furst, D E: 5 articles (10/2006 - 11/2000)
6.	Medsger, T A: 5 articles (10/2006 - 11/2000)
7.	Barbosa, Egberto Reis: 4 articles (01/2024 - 04/2012)
8.	Schilsky, Michael L: 4 articles (12/2023 - 08/2007)
9.	Weiss, Karl Heinz: 4 articles (12/2022 - 08/2013)
10.	Yang, Wenming: 4 articles (10/2022 - 02/2018)

Related Diseases

1.	Rheumatoid Arthritis 07/01/1985 - "In 52 patients with severe rheumatoid arthritis the therapeutic efficacy of 600 mg/die of D-penicillamine was evaluated for two years in a prospective trial. " 09/01/1994 - "Intermittent treatment with D-penicillamine is effective in lower doses and with fewer adverse effects in patients with rheumatoid arthritis." 10/14/1988 - "D-penicillamine is also effective in controlling the signs and symptoms of rheumatoid arthritis, but serious toxicity may occur. " 01/01/1988 - "The mechanism by which D-Penicillamine is effective in the treatment of rheumatoid arthritis has been investigated. " 11/01/1986 - "In 34 patients with severe rheumatoid arthritis the therapeutic efficacy of 600 mg/die of D-penicillamine was evaluated for five years. "
2.	Hepatolenticular Degeneration (Wilson's Disease) 05/01/2009 - "Nevertheless, according to currently available data, patients with hepatic presentation of Wilson disease are probably most effectively treated by D-penicillamine. " 04/12/1986 - "A patient who presented with severe hepatic Wilson's disease at age 14 responded well to treatment with penicillamine and remained in good health for a further 20 years, although she became somewhat careless about her medication towards the end of this period. " 01/01/2022 - "TETA-2HCl is well-tolerated and effective in Wilson disease patients following the withdrawal of treatment with D-penicillamine. " 01/01/2017 - "This historical review describes Professor Walshe's seminal contribution to the treatment of Wilson's disease on the 60th anniversary of his pioneering article on penicillamine, the first effective treatment for the condition." 06/28/1999 - "Treatment with penicillamine in Indian childhood disease, which probable has the same etiology, is effective when it is started early enough as well as in Wilson's disease. "
3.	Lead Poisoning (Poisoning, Lead) 09/01/2009 - "The use of d-Penicillamine was proved highly effective in treating a case of lead poisoning." 07/01/2019 - "d-Penicillamine was effective in the treatment of lead poisoning among children. " 01/01/2019 - "Background The aim of the current study was to evaluate the efficacy of D-penicillamine in the treatment of lead poisoning mainly in the outpatient setting. " 01/01/2019 - "Methods In a case series study performed during the recent epidemic of lead poisoning in Iran, lead-poisoned patients referring to our outpatient clinic were treated with 250-mg D-penicillamine capsules administered every 6 h for 5 or 10 days based on availability of the medication. " 01/01/2019 - "Conclusions D-penicillamine may be an acceptable substitute treatment in adult lead poisoning. "
4.	Cystinuria 01/01/1993 - "Long-term D-penicillamine treatment can be used in patients with cystinuria and is both effective and safe. " 11/01/1981 - "We conclude that D-penicillamine is useful in the treatment of cystinuria. " 11/01/1981 - "A retrospective study was conducted to assess the efficacy of D-penicillamine in the management of cystinuria, as well as to define the frequency and nature of untoward reactions to this drug. " 12/01/2008 - "We reviewed the charts of all 11 children with cystinuria treated at our clinic using a gradual dose escalation of penicillamine. " 12/01/2008 - "We evaluated the effects of penicillamine in preventing stone formation and with respect to toxicity in our cystinuria cohort at a pediatric biochemical genetics clinic. "
5.	Arthritis (Polyarthritis) 03/01/1978 - "On the basis or a study of 50 cases of rheumatoid polyarthritis treated with D penicillamine comments are made on the failure of this form of treatment by comparison of the apparent and real efficacy. " 12/01/1977 - "[Study of optimal posology of penicillamine in the treatment of common rheumatoid polyarthritis (apropos of a personal series of 200 cases)]." 03/01/1975 - "[Multicentric ambulatory trial of Trolovol (D-penicillamine) in chronic polyarthritis]." 10/01/1972 - "[Study of various parameters of cellular and humoral immunity during the treatment of rheumatoid polyarthritis with D-penicillamine]." 02/01/1970 - "[Penicillamine and rheumatoid polyarthritis (study of 9 cases)]."

Related Drugs and Biologics

1.	Zinc
2.	Copper
3.	Chelating Agents
4.	Gold
5.	Salts
6.	Methotrexate (Mexate)
7.	Hydroxychloroquine (Plaquenil)
8.	Trientine (Trien)
9.	Dimercaprol (B.A.L.)
10.	Azathioprine (Imuran)

Related Therapies and Procedures

1.	Therapeutics
2.	Chelation Therapy (Therapy, Chelation)
3.	Plasmapheresis
4.	Drug Therapy (Chemotherapy)
5.	Oral Administration