Morphine (MS Contin)

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

Also Known As:

MS Contin; Morphia; Duramorph; Morphine Sulfate; Morphine Chloride; Morphine Sulfate (2:1), Anhydrous; Morphine Sulfate (2:1), Pentahydrate; Oramorph SR; SDZ 202-250; SDZ202-250; Chloride, Morphine; Contin, MS; SDZ 202 250; SDZ 202250; SDZ202 250; SDZ202250; Sulfate, Morphine; Morphinan-3,6-diol, 7,8-didehydro-4,5-epoxy-17-methyl- (5alpha,6alpha)-

Networked: 19141 relevant articles (1727 outcomes, 3084 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Zarrindast, Mohammad-Reza: 41 articles (07/2023 - 05/2002)
2.	Currow, David C: 40 articles (03/2024 - 09/2003)
3.	Bruera, Eduardo: 38 articles (05/2023 - 09/2003)
4.	Suzuki, Tsutomu: 38 articles (07/2022 - 09/2002)
5.	Mika, Joanna: 36 articles (05/2023 - 05/2004)
6.	Roy, Sabita: 35 articles (03/2024 - 09/2003)
7.	Wong, Chih-Shung: 35 articles (07/2023 - 06/2002)
8.	Mercadante, Sebastiano: 33 articles (10/2023 - 05/2002)
9.	Porreca, Frank: 31 articles (09/2023 - 08/2002)
10.	Rezayof, Ameneh: 30 articles (01/2023 - 08/2004)

Related Diseases

1.	Pain (Aches) 09/30/2019 - "Morphine is the most effective medication to relieve pain, antinociception and withdrawal syndrome, but clinical application of these compounds is greatly affected by the occurrence of addiction. " 01/01/2019 - "Topical morphine was found to be a fast acting, highly effective, and safe medication for mucosal and skin lesions in palliative patients, with a sustainable pain relief effect over the 28-day observation period." 01/01/2017 - "Morphine was the most effective in the improvement in some of the Brief Pain Inventory-Short Form items regarding negative impact of pain on patients' daily activities. " 12/01/2007 - "For BTP, a mean dose of 28 mg of effervescent morphine (range 10-80 mg) resulted in a highly significant reduction of pain score (mean 7.8 to mean 3.2; P < 0.001). " 02/01/1985 - "One to two milligrams of intrathecal morphine dramatically relieved their spasticity and pain. "
2.	Postoperative Pain 01/01/2021 - "PNC use in amputees is associated with a significant reduction in post-operative pain scores and post-operative morphine requirements, although this latter finding is lost on sensitivity analysis of randomised trials only." 06/01/1990 - "Epidural morphine is effective in the treatment of postoperative pain, but the incidence of associated side effects is high. " 04/01/2011 - "Postoperative pain, morphine use, disease-free and overall survival, and surgical and hospital costs were measured postoperatively and compared between the two groups. " 04/24/2024 - "The two administration settings of morphine sulphate by PCA pump have shown to be equally effective in the treatment of postoperative pain following PSF. " 01/01/2016 - "Epidural morphine is effective in controlling postoperative pain, but can further reduce gastrointestinal motility. "
3.	Cancer Pain 11/01/1993 - "Intrathecal mu agonists, particularly morphine, are effective for most patients with cancer pain, though in some patients rapid tolerance or marked resistance develop. " 06/01/2021 - "The cisterna Intrathecal Drug Delivery system (IDDS) with morphine has proven to be effective in treating refractory cancer pain above the middle thoracic vertebrae level in some countries. " 09/01/2020 - "60% of the providers were certain that cancer pain cannot be relieved by morphine while only 33% believed that morphine can cause complete relief. " 04/01/2001 - "In paediatric haematology/oncology, pain control by oral long-acting morphine proved to be safe and effective even in the very young patients. " 02/01/2021 - "Targeting microglia different polarization states by the inhibition of their deleterious pro-inflammatory neurotoxicity and/or enhancing their beneficial anti-inflammatory protective function seems to be an effective treatment for cancer pain and morphine tolerance."
4.	Neoplasms (Cancer) 10/01/2019 - "Since UGT2B7 plays an important role in the metabolism of morphine, UGT2B7 gene mutation may influence the efficacy of morphine in patients with cancer being treated by this medication. " 10/01/2016 - "Association of the OPRM1 and COMT genes' polymorphisms with the efficacy of morphine in Tunisian cancer patients: Impact of the high genetic heterogeneity in Tunisia?" 01/01/2012 - "In contrast, the values of VAS in response to 0.00075 g x kg(-2) of morphine in patients with P-gp(+) tumors were significantly greater than those in the patients with P-gp(-) tumors, although similar levels of plasma morphine were detected in both groups of patients. " 01/01/1992 - "Pharmacokinetics and efficacy of rectal versus oral sustained-release morphine in cancer patients." 07/01/1989 - "The use of controlled-release morphine administered at regular 12-hour intervals offers an additional method of providing prolonged comfort with the associated overall improvement in quality of life of the cancer patient."
5.	Pruritus (Itching) 02/01/2022 - "The Incidence of Itching in Thoracic Epidural Morphine Applications: Can Laboratory Parameters Be Effective in Predicting Itching?" 01/01/2023 - "Our objective was to perform an updated systematic review and network meta-analysis to provide clinicians with a comparison of relative efficacy of available interventions to reduce the incidence of pruritus, induced by either intrathecal or epidural single-shot morphine, in women undergoing Caesarean delivery. " 01/01/2019 - "Therefore, we propose that EA may be involved in the remission of pruritus in morphine-induced pruritus model mice through the TLR2/4-MyD88-NF-κB pathway. " 01/01/2022 - "We identified clinical trials investigating the prevention or treatment of neuraxial morphine-induced pruritus in adults. " 02/01/2021 - "Medications for the prevention of pruritus in women undergoing cesarean delivery with Intrathecal morphine: A systematic review and bayesian network meta-analysis of randomized controlled trials."

Related Drugs and Biologics

1.	Analgesics (Analgesic Drugs)
2.	Opioid Analgesics (Opioids)
3.	Fentanyl (Sublimaze)
4.	Bupivacaine (Bupivacaine Hydrochloride)
5.	Ketamine
6.	Oxycodone (Oxycontin)
7.	Acetaminophen (Paracetamol)
8.	Ketorolac
9.	Methadone (Dolophine)
10.	Naloxone (Narcan)

Related Therapies and Procedures

1.	Analgesia
2.	Therapeutics
3.	Patient-Controlled Analgesia (Analgesia, Patient Controlled)
4.	Pain Management
5.	Cesarean Section (Caesarean Section)