Hydrogen Peroxide (Hydroperoxide)

A strong oxidizing agent used in aqueous solution as a ripening agent, bleach, and topical anti-infective. It is relatively unstable and solutions deteriorate over time unless stabilized by the addition of acetanilide or similar organic materials.

Also Known As:

Networked: 6889 relevant articles (276 outcomes, 774 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Spitz, Douglas R: 24 articles (11/2023 - 07/2005)
2.	Ogawa, Yasuhiro: 22 articles (06/2017 - 10/2003)
3.	Liu, Bin: 17 articles (02/2024 - 04/2004)
4.	Chen, Yu: 17 articles (01/2024 - 01/2008)
5.	Buettner, Garry R: 17 articles (08/2023 - 08/2005)
6.	Li, Wei: 17 articles (01/2023 - 05/2011)
7.	Nishioka, Akihito: 17 articles (07/2016 - 10/2003)
8.	Sultana, Sarwat: 15 articles (01/2007 - 03/2003)
9.	Chen, Wei: 13 articles (05/2024 - 01/2008)
10.	Wang, Wei: 13 articles (03/2024 - 09/2006)

Related Diseases

1.	Neoplasms (Cancer) 05/15/2024 - "The therapeutic efficacy of Fenton or Fenton-like nanocatalysts is usually restricted by the inappropriate pH value and limited concentration of hydrogen peroxide (H2O2) at the tumor site. " 02/09/2024 - "However, the low concentration of hydrogen peroxide (H2O2) in the tumor site suppresses the therapeutic efficacy of CDT. " 08/11/2021 - "However, owing to the insufficient amount of endogenous hydrogen peroxide (H2O2) in tumor cells, the efficacy of CDT was limited. " 01/31/2018 - "The microenvironment responsiveness to both pH and hydrogen peroxide makes the NPs biodegradable in tumor tissues, and the framework should be easily cleared by the body. " 12/07/2001 - "Despite previous reports on tumor-derived cell lines, overexpression of Apo J in human fibroblasts did not provide protection against apoptosis or growth arrest induced by hydrogen peroxide. "
2.	Neuroblastoma 05/01/2019 - "At cellular level compound 4 (1 μM) showed significant protective effects in neuroblastoma SH-SY5Y cell line when treated with hydrogen peroxide (400 μM). " 11/01/2019 - "The present study was designed to explore the protective effects of NGN against hydrogen peroxide (H2O2)-induced neurotoxicity in human neuroblastoma SH-SY5Y cells and the possible mechanisms involved. " 11/01/2020 - "Herein, the mechanisms underlying the protective effects of SPI against oxidative stress induced by hydrogen peroxide (H2 O2 ) were examined in neuro-2a (N2a) mouse neuroblastoma cells. " 01/01/2019 - "Cistanche extracts ameliorates the neurotoxicity induced by hydrogen peroxide in new mutant DJ-1-transfected neuroblastoma cellular models." 02/01/2005 - "In this study, neuroblastoma SH-SY5Y cells were treated with hydrogen peroxide in the presence of ascorbate in order to elucidate the mechanism(s) of protection against oxidative stress afforded by ascorbate. "
3.	Wounds and Injuries (Trauma) 03/01/2014 - "The aim of this study was to evaluate the efficacy of hydrosurgery prepared with or without hydrogen peroxide for the management of subacute and chronic wounds. " 03/01/1986 - "[Evaluation of the efficacy of wound treatment by the intensity of chemiluminescence in the presence of hydrogen peroxide]." 01/01/2020 - "Previous studies have revealed that p53 signalling is activated during cardiac regeneration in neonatal mice and that hydrogen peroxide (H2O2) generated near the wound site acts as a novel signal to promote zebrafish heart regeneration. " 05/01/2018 - "This study used a multifactorial design to examine the cellular responses of Staphylococcus aureus to hydrogen peroxide (0-100 mM) when bacteria were grown in temperatures of 37 ± 2 °C and pH 7 ± 1, conditions potentially encountered in wound sites. " 03/01/2014 - "The wounds were debrided using hydrosurgery prepared with (the study group) or without hydrogen peroxide before grafting the wound (the control group). "
4.	Hypoxia (Hypoxemia) 06/01/2006 - "Moreover, Ad-hTERT significantly improved survival of primary rabbit dermal fibroblasts that were treated with hypoxia and hydrogen peroxide (oxidative stress). " 01/01/2021 - "However, hypoxia and a limited amount of hydrogen peroxide (H2O2) in the tumor microenvironment (TME) severely restrict the therapeutic efficacy of this combined treatment. " 01/01/2019 - "The purpose of this study was to develop an in vitro model to study the progressive morphological and functional changes of adipocytes with aging, in standard culture conditions and after severe hypoxia and hydrogen peroxide treatment. " 01/01/2018 - "Therefore, in this study we aimed to test whether different patterns of hypoxia and/or putative microglial modulators change extracellular hydrogen peroxide in the ventrolateral medulla by using an enzymatic reactor online sensing procedure specifically designed for this purpose. " 12/19/2017 - "In addition, down-regulation and up-regulation of miR143 expression and hydrogen peroxide induced hypoxia injury were carried out on L02 cells to study the role of miR143. "
5.	Infections 02/01/2013 - "Using hydrogen peroxide improved local control and infection rates, but the difference was not statistically significant." 05/01/2015 - "In flies infected with protective Wolbachia strains, hydrogen peroxide concentrations were 1.25- to 2-fold higher than those in paired fly lines cured of Wolbachia infection. " 05/01/2015 - "In contrast, there was no difference in the hydrogen peroxide concentrations in flies infected with nonprotective Wolbachia strains compared to flies cured of Wolbachia infection. " 07/01/2014 - "Despite this reduction in phagocytosis capacity, macrophages from tolerant animals exhibited enhanced hydrogen peroxide production and expression of antigen presentation molecules, suggesting that their ability to combat an infection is improved. " 01/31/2024 - "In the present study, we demonstrated that SCMV infection upregulates the expression of ScRBOHs and the accumulation of hydrogen peroxide (H2O2), which inhibits SCMV replication. "

Related Drugs and Biologics

1.	Glutathione (Reduced Glutathione)
2.	Hydroxyl Radical
3.	Oxygen (Dioxygen)
4.	Reactive Oxygen Species (Oxygen Radicals)
5.	Antioxidants
6.	Enzymes
7.	Solutions
8.	Superoxide Dismutase
9.	Malondialdehyde (Propanedial)
10.	Peroxidase (Myeloperoxidase)

Related Therapies and Procedures

1.	Therapeutics
2.	Radiotherapy
3.	Tooth Bleaching
4.	Drug Therapy (Chemotherapy)
5.	Photochemotherapy (Photodynamic Therapy)