Formaldehyde (Formol)

A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)

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Networked: 19515 relevant articles (402 outcomes, 2421 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Ross, Jeffrey S: 35 articles (01/2023 - 03/2002)
2.	Haghparast, Abbas: 33 articles (02/2024 - 07/2006)
3.	Granados-Soto, Vinicio: 33 articles (01/2019 - 01/2002)
4.	Hartmann, Arndt: 31 articles (01/2023 - 04/2005)
5.	Fountzilas, George: 31 articles (03/2021 - 08/2008)
6.	Zhang, Wei: 27 articles (12/2023 - 11/2003)
7.	Weichert, Wilko: 27 articles (06/2023 - 09/2003)
8.	Butkevich, I P: 27 articles (07/2020 - 06/2001)
9.	He, Rongqiao: 24 articles (05/2023 - 12/2010)
10.	Schirmacher, Peter: 24 articles (01/2022 - 07/2007)

Related Diseases

1.	Pain (Aches) 06/27/2017 - "canariensis extract, orally administrated at different doses, led to a significant reduction in writhing, caused a moderate decrease of formalin-induced pain and revealed an excellent dose-dependent anti-inflammatory effect. " 10/15/2012 - "Relative to the NTg controls, GET-1 mice displayed a marked decrease in pain-like behavioral responses during the second phase of formalin-induced pain (i.e., 15-20 min after injection), whereas the responses elicited in TET-1 mice were unaltered. " 01/01/2022 - "Exogenous intrathecal GRP infusion to the paw-formalin injection model not only showed significant reduction of pain behavior but also increased c-Fos in the inhibitory neurons in the dorsal horn. " 10/17/2019 - "This resulted in significant pain relief for mice in the phase II period of formalin response tests. " 01/01/2016 - "A significant reduction in pain behavior was demonstrated after administration of 8.4 mg/kg in the formalin test. "
2.	Neoplasms (Cancer) 01/01/2019 - "We examined whether the introduction of an audit and feedback strategy applied to specimens dissected at the John Hunter Hospital anatomical pathology department improved the number of formalin fixed tumor specimens sampled by anatomical pathology registrars for the Hunter Cancer Biobank. " 01/01/2001 - "In negative 10% formalin-fixed tissues, microwave treatment improved the positivity of 654-1-stained cancer cells. " 06/01/1994 - "We describe here an improved technique for interphase FISH analysis of tumors that have been extensively fixed in formalin. " 12/01/1989 - "In a pilot study, we demonstrated improvement in tumor definition and staining characteristics after formalin fixation of cryostat sections (postfixation) when compared with unfixed specimens. " 01/01/1988 - "Eubacterium lentum (TYH-11), Propionibacterium acnes (TYM-28), Proteus mirabilis (TYM-7) and Serratia marcescens (TY-142), in which antitumor activity was recognized with living and formalin-killed bacteria, cured the tumor-bearing mice, and the culture supernatant of S. "
3.	Infections 01/01/2021 - "Intranasal immunization of RADVAXFluA provided better protection against influenza virus infection than formalin-inactivated influenza virus (FIV) in mice. " 01/01/1977 - "Nude (nu/nu) mice fail to resist to challenge infection of Tyzzer's disease after pretreatment with formalin-killed organisms that was effective for protecting heterozygous haired (nu/ł) mice from challenge. " 01/01/2019 - "Protective effects of oral immunization with formalin-inactivated whole-cell Citrobacter rodentium on Citrobacter rodentium infection in mice." 01/01/2016 - "Our results suggest that intraperitoneal immunization with formalin-inactivated VERv could be a safe and effective strategy to fight Betanodavirus infection in European sea bass." 03/01/2010 - "Subcutaneous immunization against Leishmania major - infection in mice: efficacy of formalin-killed promastigotes combined with adjuvants."
4.	Hyperalgesia 08/23/2012 - "SA is effective in reducing formalin-induced mechanical allodynia and spinal neuronal hyperactivity. " 01/01/2020 - "The present study findings suggest that chronic stress induces mechanical and formalin-evoked acute hyperalgesia of female rats in an estrous cycle-dependent manner.SUMMARYOur studies showed that chronic stress increased nociceptive sensitivity of female rats. " 04/01/2016 - "The purpose of this study was to determine the role of spinal 5-HT2A, 5-HT2B and 5-HT2C receptors in the development and maintenance of formalin-induced long-lasting secondary allodynia and hyperalgesia in rats, as well as their expression in the dorsal root ganglia (DRG) during this process. " 11/01/2014 - "Other four groups with the same treatments were performed in order to study the effect of MSBE on the formalin-induced long-term secondary mechano-hyperalgesia at 7 days after the injury by means of the pin-prick method. " 10/01/2013 - "The present study demonstrates that intramuscular formalin evokes biphasic muscle nociception, and that bilateral secondary mechanical hyperalgesia and heat hypoalgesia are differentially controlled by endogenous descending facilitation and inhibition respectively. "
5.	Proctitis 04/01/2007 - "APC is probably less effective in very severe cases of hemorrhagic radiation proctitis; in these cases topical formalin or a combination of APC and topical formalin can be useful. " 06/01/2005 - "Although formalin instillation has been proven to be an effective treatment of hemorrhagic radiation proctitis, different techniques with varying success rates have been reported. " 01/01/2003 - "Local application of 4% formaldehyde for the treatment of haemorrhagic radiation-induced proctitis gives good results, is well tolerated and easy to perform. " 10/01/2010 - "Local instillation of 4% formalin is an effective treatment for uncontrolled radiation induced haemorrhagic proctitis." 03/01/2007 - "Topical formalin application in the outpatient setting appears to be an effective first-line treatment for haemorrhagic radiation proctitis. "

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