Flavonoids

A group of phenyl benzopyrans named for having structures like FLAVONES.

Also Known As:

2-Phenyl-Benzopyrans; 2-Phenyl-Chromenes; 2 Phenyl Benzopyran; 2 Phenyl Benzopyrans; 2 Phenyl Chromene; 2 Phenyl Chromenes; 2-Phenyl-Benzopyran; 2-Phenyl-Chromene; Bioflavonoid; Bioflavonoids; Flavonoid

Networked: 10180 relevant articles (758 outcomes, 2013 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 207
- 1-Ring Heterocyclic Compounds
  - Pyrans: 131
    - Benzopyrans: 198
      - Chromones: 161
        Flavonoids: 10180
        Isoflavones: 2665
        Anthocyanins: 1799
        Catechin: 1328
        baicalin: 1045
        2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: 751
        Proanthocyanidins: 702
        icariin: 627
        chrysin: 600
        Flavones: 456
        alvocidib: 439
        myricetin: 439
        Chalcones: 429
        3-hydroxyflavone: 381
        Flavonols: 327
        xanthohumol: 260
        Phloretin: 208
        galangin: 207
        Flavanones: 187
        pycnogenols: 185
        icaritin: 167
        5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one: 151
        baohuoside I: 115
        flavone acetic acid: 113
        eupatilin: 108
        breviscapine: 107
        Biflavonoids: 104
        casticin: 101
        diosmetin: 96
        myricitrin: 65
        kolaviron: 64
        tricin: 64
        orientin: 63
        morusin: 62
        ampelopsin: 59
        ganhuangenin: 49
        flavan-3-ol: 41
        flavokawain B: 40
        Flavonolignans: 40
        tiliroside: 37
        tilianin: 35
        sinensetin: 34
        kurarinone: 33
        jaceosidin: 32
        aminoflavone: 27
        bavachin: 26
        didymin: 26
        gossypin: 23
        sulfuretin: 23
        galascorbin: 21
        sakuranetin: 21
        corylin: 20
        spinosin: 19
        5,7-dimethoxyflavone: 17
        avicularin: 17
        glycyrol: 17
        tectochrysin: 17
        aromadedrin: 16
        corvitin: 16
        nicotiflorin: 16
        peflavit: 16
        trilobatin: 16
        WS 1442: 16
        herbacetin: 15
        8-bromo-7-methoxychrysin: 14
        eupatorin: 14
        gossypetin: 14
        poncirin: 14
        artemetin: 13
        recoflavone: 13
        procyanidin trimer C1: 12
        3,3',4',5,6,7,8-heptamethoxyflavone: 11
        7-hydroxyflavone: 11
        bilobetin: 11
        hydroxygenkwanin: 11
        3,6-dihydroxyflavone: 10
        epimedin C: 10
        irisolidone: 10
        isosakuranetin: 10
        kuwanon G: 10
        orobol: 10
        apple polyphenol extract: 9
        artonin E: 9
        fustin: 8
        isobavachin: 8
        maysin: 8
        6-prenylnaringenin: 7
        dimefline: 7
        epimedin B: 7
        santin: 7
        sudachitin: 7
        vestitol: 7
        6-methoxy-4',5-dihydroxyflavone-7-O-glucoside: 6
        boeravinone B: 6
        cudraflavone B: 6
        enzogenol: 6
        furowanin A: 6
        icarrin: 6
        kurarinol: 6
        LM 985: 6
        morusinol: 6
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 198
      - Chromones: 161
        Flavonoids: 10180
        Isoflavones: 2665
        Anthocyanins: 1799
        Catechin: 1328
        baicalin: 1045
        2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one: 751
        Proanthocyanidins: 702
        icariin: 627
        chrysin: 600
        Flavones: 456
        alvocidib: 439
        myricetin: 439
        Chalcones: 429
        3-hydroxyflavone: 381
        Flavonols: 327
        xanthohumol: 260
        galangin: 207
        Flavanones: 187
        pycnogenols: 185
        icaritin: 167
        5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one: 151
        baohuoside I: 115
        flavone acetic acid: 113
        eupatilin: 108
        breviscapine: 107
        Biflavonoids: 104
        casticin: 101
        diosmetin: 96
        myricitrin: 65
        kolaviron: 64
        tricin: 64
        orientin: 63
        morusin: 62
        ampelopsin: 59
        ganhuangenin: 49
        flavan-3-ol: 41
        flavokawain B: 40
        Flavonolignans: 40
        tiliroside: 37
        tilianin: 35
        sinensetin: 34
        kurarinone: 33
        jaceosidin: 32
        aminoflavone: 27
        bavachin: 26
        didymin: 26
        gossypin: 23
        sulfuretin: 23
        galascorbin: 21
        sakuranetin: 21
        corylin: 20
        spinosin: 19
        5,7-dimethoxyflavone: 17
        avicularin: 17
        glycyrol: 17
        tectochrysin: 17
        aromadedrin: 16
        corvitin: 16
        nicotiflorin: 16
        peflavit: 16
        trilobatin: 16
        WS 1442: 16
        herbacetin: 15
        8-bromo-7-methoxychrysin: 14
        eupatorin: 14
        gossypetin: 14
        poncirin: 14
        artemetin: 13
        recoflavone: 13
        procyanidin trimer C1: 12
        3,3',4',5,6,7,8-heptamethoxyflavone: 11
        7-hydroxyflavone: 11
        bilobetin: 11
        hydroxygenkwanin: 11
        3,6-dihydroxyflavone: 10
        epimedin C: 10
        irisolidone: 10
        isosakuranetin: 10
        kuwanon G: 10
        orobol: 10
        apple polyphenol extract: 9
        artonin E: 9
        fustin: 8
        isobavachin: 8
        maysin: 8
        6-prenylnaringenin: 7
        dimefline: 7
        epimedin B: 7
        santin: 7
        sudachitin: 7
        vestitol: 7
        6-methoxy-4',5-dihydroxyflavone-7-O-glucoside: 6
        boeravinone B: 6
        cudraflavone B: 6
        enzogenol: 6
        furowanin A: 6
        icarrin: 6
        kurarinol: 6
        LM 985: 6
        morusinol: 6
        robinin: 6

Experts

1.	Guo, Qinglong: 44 articles (10/2023 - 05/2009)
2.	Lu, Na: 37 articles (06/2023 - 05/2009)
3.	Zhang, Li: 30 articles (11/2023 - 07/2003)
4.	Li, Zhiyu: 30 articles (11/2023 - 06/2011)
5.	Hodgson, Jonathan M: 28 articles (01/2023 - 08/2005)
6.	Scalbert, Augustin: 26 articles (01/2023 - 01/2005)
7.	Cassidy, Aedín: 24 articles (12/2023 - 07/2008)
8.	Wang, Ying: 24 articles (11/2023 - 01/2012)
9.	Zhao, Li: 23 articles (12/2023 - 12/2006)
10.	Wang, Jing: 22 articles (02/2024 - 01/2013)

Related Diseases

1.	Neoplasms (Cancer) 11/08/2016 - "Although numerous in vitro studies and animal model data have suggested that flavan-3-ols, the most common subclass of flavonoids in the diet, may exert protective effects against cancer, epidemiologic studies have reported inconclusive results for the association between flavan-3-ols intake and cancer risk. " 11/30/2022 - "Flavonoids are plant-derived natural compounds that exhibited enormous anti-cancerous potential against several human cancers. " 03/01/2020 - "Aside from the relatively low rate of complete response (CR) or partial response (PR) with any administration protocol, flavonoids showed higher positive outcomes for hematopoietic and lymphoid tissues (140 patients with CR and 88 with PR among 615 patients in 11 trials) than for solid tumors (4 patients with CR and 21 with PR among 525 patients in 12 trials). " 03/01/2020 - "However, because of the high variety in administration schedule, more studies are needed to further understand how flavonoids can promote positive outcomes for cancer patients." 11/01/2010 - "Although flavonoids exert protective effects against IR in normal cells, they enhance genotoxicity effects of this radiation in cancer cells, a beneficial effect that is of interest in the design of new anticancer pharmaceuticals. "
2.	Inflammation (Inflammations) 03/01/2024 - "However, the flavonoids significantly decreased the severity of airway inflammation. " 10/16/2020 - "Since it is known that diabetes induces oxidative stress and inflammation in the retina leading to neuronal death in the early stages of the disease, the use of these compounds can prove to be beneficial in the prevention or treatment of DR. In this review, we summarize the molecular and cellular effects of flavonoids in the diabetic retina." 01/01/2019 - "High Flavonoid Cocoa Supplement Ameliorates Plasma Oxidative Stress and Inflammation Levels While Improving Mobility and Quality of Life in Older Subjects: A Double-Blind Randomized Clinical Trial." 01/23/2018 - "Flavonoid-rich KRT may be a beneficial treatment for infectious skin inflammation." 01/01/2018 - "Flavonoids are well-researched secondary plant metabolites that appear to be effective in reducing levels of oxidative stress and inflammation in neural cells. "
3.	Cardiovascular Diseases (Cardiovascular Disease) 01/01/2021 - "Hence, it is important to study the relationship between gut microbiota and flavonoids to elucidate the protective effects of flavonoids in cardiovascular diseases. " 05/01/2012 - "These findings suggest that dietary flavonoids, despite their limited oral bioavailability and very low postabsorption plasma concentrations, may provide protection against oxidative stress-based cardiovascular diseases. " 02/05/2017 - "This activity may be responsible, at least in part, for the beneficial and protective effects of dietary flavonoids toward cardiovascular diseases highlighted in several epidemiological studies. " 01/01/2012 - "In this study, we explored potential mechanisms and protective effects of total flavonoids of Astragalus (TFA) on cardiovascular disease using in vitro experiments and diet-induced atherosclerotic rabbits. " 07/16/2022 - "As a non-pharmacological approach, diet, especially a flavonoid-rich diet, showed promising results in the reduction of cardiovascular diseases and alleviation of their symptoms. "
4.	Obesity 01/01/2023 - "Flavonoids have been shown to be beneficial in the prevention and treatment of obesity. " 01/01/2021 - "Significant evidence suggests protective effects of flavonoids against obesity in animal models, but these often do not translate to humans. " 06/09/2010 - "Improvement in high-fat diet-induced obesity and body fat accumulation by a Nelumbo nucifera leaf flavonoid-rich extract in mice." 04/24/2024 - "This study aimed to characterize the constituents in flavonoids from blossom of CAVA (CAVAF) and to clarify the anti-obesity capacities especially the effects on browning of WAT. " 01/12/2024 - "In this study, obesity model rats are used to conduct scientific pharmacological research on hawthorn flavonoids. "
5.	Insulin Resistance 01/01/2014 - "The improvement in insulin resistance induced by this flavonoid is not mediated by a delipidating effect in skeletal muscle. " 11/25/2019 - "The purpose of this study was to assess the potential of mixed berries to improve insulin sensitivity and to identify the potential role of flavonoids and fiber. " 04/26/2019 - "Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials." 04/01/2012 - "Data from mechanistic studies support a beneficial effect of specific flavonoids on insulin sensitivity. " 02/01/2024 - "Prenylated flavonoid fractions from Glycyrrhiza glabra alleviate insulin resistance in HepG2 cells by regulating the ERK/IRS-1 and PI3K/Akt signaling pathways."

Related Drugs and Biologics

1.	Antioxidants
2.	Quercetin
3.	Apigenin
4.	Phytochemicals
5.	Polyphenols
6.	Glycosides
7.	Luteolin
8.	naringenin
9.	Alkaloids
10.	Hesperidin

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Chinese Traditional Medicine (Traditional Chinese Medicine)
4.	Chemoprevention
5.	Hemorrhoidectomy