Estrogens (Estrogen)

Compounds that interact with ESTROGEN RECEPTORS in target tissues to bring about the effects similar to those of ESTRADIOL. Estrogens stimulate the female reproductive organs, and the development of secondary female SEX CHARACTERISTICS. Estrogenic chemicals include natural, synthetic, steroidal, or non-steroidal compounds.

Also Known As:

Networked: 41986 relevant articles (1704 outcomes, 5669 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Sasano, Hironobu: 120 articles (03/2022 - 01/2002)
2.	Suzuki, Takashi: 96 articles (07/2023 - 01/2002)
3.	Jordan, V Craig: 84 articles (01/2023 - 01/2002)
4.	Miki, Yasuhiro: 70 articles (07/2023 - 12/2002)
5.	Chlebowski, Rowan T: 69 articles (04/2024 - 01/2002)
6.	Hankinson, Susan E: 66 articles (01/2022 - 05/2002)
7.	Manson, JoAnn E: 65 articles (04/2024 - 05/2003)
8.	Stanczyk, Frank Z: 64 articles (01/2023 - 09/2002)
9.	Dowsett, Mitch: 60 articles (12/2019 - 01/2002)
10.	Xu, Xia: 59 articles (06/2023 - 10/2004)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2017 - "Our studies indicate that combinatorial bioactive botanicals from GTPs and BSp are highly effective in inhibiting ERα-negative breast cancer due at least in part to epigenetic reactivation of ERα, which in turn increases TAM-dependent anti-estrogen chemosensitivity in vitro and in vivo." 03/01/2000 - "The current study was conducted to investigate the efficacy of GAP31 and MAP30 on estrogen-independent and highly metastatic human breast tumor MDA-MB-231 both in vitro and in vivo. " 05/01/1992 - "The results of this study with human breast cancer cells suggest that 5a may be highly effective in the treatment of estrogen-dependent breast cancer and/or in the prophylactic treatment of women with a high risk of breast cancer development." 04/01/2024 - "One of the best treatment strategies for treating Estrogen-positive breast cancer is blocking Estrogen signaling. " 01/01/2018 - "Inhibition of estrogen activity by small molecules with increased target specificity has proven to be an effective treatment for breast cancer. "
2.	Neoplasms (Cancer) 01/01/2004 - "In particular, we found a marked decrease in the number of apoptotic cells and debris after estrogen + irradiation, as compared to irradiation alone, only in younger patients and TNM 1+2 tumors. " 03/01/2023 - "The combined use of AI and COS is beneficial for oocyte cryopreservation in patients with estrogen-sensitive cancer, regardless of the menstrual cycle phase of COS initiation." 01/01/2019 - "Further subgroup analysis revealed that high serum estrogen was significantly associated with improved survival in dogs with ER positive tumors, but only in spayed dogs (p = 0.0052). " 02/13/2015 - "The findings suggest that selective inhibitors of transactivation by ER may be more beneficial in reducing tumor progression than conventional anti-estrogens that also antagonize E2-dependent transrepression. " 12/01/2005 - "Approaches to perturb the estrogen environment are successful usually in the remission of established tumors. "
3.	Osteoporosis 03/03/2024 - "Interestingly, Piezo1 activation also exhibits remarkable efficacy in the treatment of alveolar bone osteoporosis caused by estrogen deficiency, which is highly prevalent among middle-aged and elderly women. " 01/01/2015 - "Osteoporosis is one of the most frequent diseases in postmenopausal women, leading to an increased fracture risk due to the physiologic loss of the bone protective effects of estrogen. " 09/01/2009 - "Currently, the nonhuman primate is the most widely used large animal model to evaluate the safety and efficacy of new drug entities to treat or prevent estrogen-deficiency-induced bone loss and osteoporosis. " 01/01/2008 - "Because of the striking resemblance of skeletal responses in humans and rats in the state of estrogen deficiency, the ovx rat is considered to be a gold standard model for evaluating drugs for prevention and reversal of osteoporosis. " 01/01/2019 - "We also highlight that increasing miR-29a function in osteoblasts is beneficial for bone anabolism to fend off estrogen deficiency-induced excessive osteoclastic resorption and osteoporosis."
4.	Atrophy 01/01/2023 - "The maximum score for most bothersome atrophy symptom (among those with baseline symptoms and adherent to study cream) improved slightly more with intravaginal estrogen (adjusted mean difference, -0.33 points; 95% confidence interval, -0.98 to 0.31), but this was not statistically significant (P=.19). " 12/01/2008 - "Low-dose vaginal estrogens are highly effective for genitourinary atrophy symptoms, with minimal systemic absorption and endometrial effects." 12/01/2003 - "Estrogen-based treatments are extremely effective for vasomotor symptom relief and for vaginal atrophy. " 11/01/2005 - "Urogenital atrophy is an important consequence of oestrogen deprivation that can be effectively treated by vaginal estrogens, although systemic absorption occurs with conventional doses. " 05/01/2013 - "Symptoms related to vaginal atrophy are a significant problem for postmenopausal women and estrogen has been the gold standard for its treatment. "
5.	Cardiovascular Diseases (Cardiovascular Disease) 01/01/2014 - "Epidemiological studies have shown that estrogens have protective effects in cardiovascular diseases, even though the results from human clinical trials remain controversial, while most of the animal experiments confirmed this effect, but the detailed mechanism remains unclear. " 10/01/2003 - "At the cellular level, estrogens have many effects on cardiovascular cells capable of being interpreted as beneficial in terms of cardiovascular disease. " 01/01/2010 - "Cardiovascular disease (CVD) is more common in postmenopausal than premenopausal women, suggesting vascular protective effects of estrogen. " 11/01/2008 - "Cardiovascular disease (CVD) is more prevalent in postmenopausal than premenopausal women, suggesting vascular protective effects of estrogen. " 03/01/2000 - "Clinicians have long suspected that the delay of a decade or more in cardiovascular disease expression in women relative to men is due to the protective effects of estrogen prior to menopause. "

Related Drugs and Biologics

1.	Progestins (Progestagens)
2.	Estrogens (Estrogen)
3.	Tamoxifen
4.	Hormones (Hormone)
5.	Progesterone
6.	Estrogen Receptors
7.	Progesterone Receptors (Progesterone Receptor)
8.	Estradiol (Delestrogen)
9.	Aromatase Inhibitors
10.	Androgens

Related Therapies and Procedures

1.	Therapeutics
2.	Hormone Replacement Therapy (Therapy, Hormone Replacement)
3.	Estrogen Replacement Therapy
4.	Drug Therapy (Chemotherapy)
5.	Ovariectomy (Oophorectomy)