Combined Modality Therapy

The treatment of a disease or condition by several different means simultaneously or sequentially. Chemoimmunotherapy, RADIOIMMUNOTHERAPY, chemoradiotherapy, cryochemotherapy, and SALVAGE THERAPY are seen most frequently, but their combinations with each other and surgery are also used.

Also Known As:

Networked: 4433 relevant articles (401 outcomes, 568 trials/studies)

Relationship Network

Therapy Context: Research Results

Experts

1.	Arnold, L Eugene: 67 articles (01/2023 - 05/2002)
2.	Hechtman, Lily: 52 articles (01/2022 - 05/2002)
3.	Hinshaw, Stephen P: 49 articles (01/2023 - 01/2002)
4.	Swanson, James M: 48 articles (01/2023 - 05/2002)
5.	Molina, Brooke S G: 43 articles (01/2023 - 06/2004)
6.	Hoza, Betsy: 38 articles (01/2020 - 02/2002)
7.	Jensen, Peter S: 37 articles (02/2022 - 05/2002)
8.	Minsky, Bruce D: 34 articles (12/2021 - 02/2002)
9.	Wigal, Timothy: 27 articles (01/2020 - 05/2002)
10.	Vitiello, Benedetto: 25 articles (01/2023 - 05/2002)

Related Diseases

1.	Neoplasms (Cancer) 10/01/2019 - "Because it is still unclear how to choose the best treatment for EC patients, a multimodal treatment is necessary to improve the prospect of the malignancy, including a sequence of surgery, chemotherapy, and radiotherapy, whether alone or combination. " 04/01/2017 - "In most cases of advanced sinonasal and ventral skull base cancer, a multimodal treatment approach provides the best chance for improved outcomes. " 04/13/2016 - "A standard treatment strategy of small cell cancer of the urinary bladder is not yet well established, but a multimodal treatment of this disease is the best option compared to surgical therapy alone. " 08/01/2014 - "Advancements in radiation therapy, chemotherapy, surgery, and multimodal treatment have dramatically improved childhood cancer survival. " 02/01/2011 - "Given the lack of improvement in overall survival, continued investigation is needed to identify the cohort of pT3b patients at highest risk for cancer progression and therefore most likely to benefit from a multimodal treatment approach."
2.	Neoplasm Metastasis (Metastasis) 01/01/2022 - "Although multimodal treatments that combine surgery with chemotherapy and immunotherapy have been shown to improve survival, pathological complete response (pCR) is rare in advanced GC patients with liver metastases. " 09/01/2017 - "Patients with colorectal liver metastases (CLM) have remarkably benefited from the advances in medical multimodal treatment and surgical techniques over the last two decades leading to significant improvements in long-term survival. " 08/01/2021 - "This study aims to identify whether there is improvement in the overall survival of patients with gastrointestinal liver metastases, undergoing hepatic resection in the context of multimodal treatment strategy, as to those approached only by systemic therapy. " 08/05/2022 - "Current multimodal treatment of bone metastases is partially effective and often associated with side effects, and novel therapeutic options are needed. " 01/01/2023 - "Multimodal treatment approach consisting of total parotidectomy, ipsilateral neck dissection and adjuvant radiotherapy has been shown to improve the locoregional control of the disease and limit the propensity to distant metastasis."
3.	Pain (Aches) 01/01/2021 - "Multimodal treatment is recognized as the optimal paradigm for the management of chronic pain (CP). " 10/01/2023 - "Conclusion  Despite significant improvement in pain, disability, trunk ROM, and TIS with multimodal treatment, there was a weak correlation between posttreatment pain and function and trunk ROM and TIS. " 02/07/2020 - "A 3-month PFP multimodal treatment strategy focusing on patient education, footwear adjustment, orthoses, and simple hip muscle exercises significantly improved functional outcomes and reduced pain at a 12 month follow-up." 01/01/2020 - "After implementing a multimodal treatment, improved mental (mood) status was significantly better (Wilcoxon signed-rank test, P < . 001), despite high levels of pain (Kohlmann/Raspe) reported on admission. " 01/01/2008 - "This multimodal treatment plan did produce significant improvement in shoulder function and pain level in the short term."
4.	Rectal Neoplasms (Rectal Cancer) 01/01/2019 - "Advances in surgical technique and the development of combined-modality therapy have led to significantly improved local control in rectal cancer. " 05/01/2016 - "The long-term salvage potential for recurrent rectal cancer improved significantly over time, with the introduction of an individualized treatment algorithm of multimodal treatments and surgical salvage. " 07/01/2003 - "Despite the routine use of adjuvant chemoradiation for curatively resected stage II and III rectal cancer a significant percentage of patients ultimately fail locally and/or distally; this underscores the need for continued improvement in the efficacy of combined-modality therapy and quality of rectal cancer resection. " 09/01/1988 - "Combined modality therapy is a safe and effective regimen for those rectal tumors in the high risk category." 01/01/2004 - "Studies have supported the use of combined modality therapy as standard adjuvant care for clinical T3 rectal cancer in the preoperative setting and for patients with T3 and/or N1/N2 disease in the postoperative setting, wtih improved rates of sphincter preservation, recurrence and overall survival."
5.	Hodgkin Disease (Hodgkin's Disease) 07/01/2010 - "Primary treatment for classic Hodgkin lymphoma (HL) remains highly effective with chemotherapy alone or combined-modality therapy. " 09/01/1977 - "The use of combined modality therapy (irradiation and combinations of drugs) in the treatment of Hodgkin's disease has produced a significant improvement in survival, during which most patients lead an active and productive life. " 10/01/2010 - "Depending on stage and risk factor profile, up to 95% of patients with Hodgkin lymphoma at first presentation reach complete remission after the initial standard treatment including radiotherapy, combination chemotherapy or combined modality therapy. " 03/19/1996 - "In patients with Hodgkin's disease presenting with massive mediastinal involvement the efficacy of combined modality therapy has been proven by all research groups. " 01/15/1985 - "Combined modality therapy was used in an attempt to increase the complete remission rate and survival of previously untreated patients with Hodgkin's disease. "

Related Drugs and Biologics

1.	Pemetrexed (MTA)
2.	Opioid Analgesics (Opioids)
3.	Doxorubicin (Adriamycin)
4.	Methylphenidate (Ritalin)
5.	Cisplatin (Platino)
6.	Methotrexate (Mexate)
7.	Proteins (Proteins, Gene)
8.	Anti-Bacterial Agents (Antibiotics)
9.	Paclitaxel (Taxol)
10.	Vincristine (Oncovin)

Related Therapies and Procedures

1.	Drug Therapy (Chemotherapy)
2.	Radiotherapy
3.	Therapeutics
4.	Chemoradiotherapy
5.	Immunotherapy