Back Pain (Backache)

Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.

Also Known As:

Backache; Backaches; Pain, Back; Back Ache; Back Pain with Radiation; Back Pain without Radiation; Vertebrogenic Pain Syndrome; Ache, Back; Aches, Back; Back Aches; Back Pains; Pain Syndrome, Vertebrogenic; Pain Syndromes, Vertebrogenic; Pains, Back; Syndrome, Vertebrogenic Pain; Syndromes, Vertebrogenic Pain; Vertebrogenic Pain Syndromes

Networked: 5914 relevant articles (597 outcomes, 710 trials/studies)

Relationship Network

Disease Context: Research Results

Signs and Symptoms Pathological Conditions
- Signs and Symptoms
  - Neurologic Manifestations: 7223
    - Pain: 225883
      - Back Pain: 5914
        Low Back Pain: 9457
        Failed Back Surgery Syndrome: 447

Related Diseases

1.	Pain (Aches)
2.	Osteoporosis
3.	Low Back Pain (Lumbago)
4.	Headache (Headaches)
5.	Compression Fractures (Compression Fracture)

Experts

1.	Dougados, Maxime: 25 articles (01/2022 - 09/2005)
2.	Deyo, Richard A: 23 articles (01/2022 - 06/2003)
3.	van der Heijde, Désirée: 20 articles (02/2024 - 11/2011)
4.	Sieper, Joachim: 19 articles (01/2023 - 02/2006)
5.	McGirt, Matthew J: 14 articles (02/2024 - 02/2009)
6.	Cohen, Steven P: 14 articles (12/2023 - 12/2002)
7.	Braun, J: 14 articles (01/2022 - 01/2000)
8.	Sherman, Karen J: 14 articles (01/2021 - 06/2003)
9.	Baraliakos, Xenofon: 13 articles (01/2024 - 01/2004)
10.	Koes, Bart W: 13 articles (12/2023 - 05/2005)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Back Pain:

1.	Opioid Analgesics (Opioids)IBA 01/30/2024 - "Despite guidelines discouraging opioids as first-line treatment, opioids remain the most prescribed drugs for back pain. " 01/01/2020 - "The present study had a double objective: (1) To identify the individual factors that differentiate patients who had been prescribed opioids for the management of chronic back pain from those who had not been prescribed opioids and (2) to determine which factors make significant and independent contributions to the prediction of opioid prescribing. " 11/01/2018 - "At mean 35.7-month follow-up, 61.1% of patients reported a significant reduction of back pain and 50.0% were able to reduce their dose of opioid medications. " 01/01/2018 - "These results suggest that 10-kHz high-frequency SCS may provide significant, long-term back pain relief, improvement in disability and quality of life, and reduction in opioids for nonsurgical refractory back pain." 08/01/2020 - "Logistic regression models showed statistically significant differences in opioids receipt by race among adult patients with back pain. "
2.	Analgesics (Analgesic Drugs)IBA 12/01/2015 - "Both male and female patients reported pronounced impairment before the operation in all patient reported outcome measures, with female patients experiencing significantly greater back pain, having greater analgesic requirements and reporting significantly inferior scores in EuroQol (EQ-5D-index), EQ-visual analogue scale, most aspects of Short Form-36 and Oswestry Disabilities Index, when compared with male patients. " 04/01/2023 - "For patients receiving PNFS, a significant decrease in back pain intensity and analgesic consumption, together with a significant improvement in physical functioning, was observed upon implant of the permanent system. " 01/01/2010 - "SR was also associated with significantly greater reductions in back pain and analgesic use scores. " 08/26/1996 - "There was a decreased use of medical treatment for back pain following the program, with 42 % of the patients refraining from the intake of analgesics, followed by a significant reduction in physiotherapy and the consultation of physicians. " 03/01/2015 - "The secondary objective was to assess the analgesic efficacy of this technique on the global and back pain components. "
3.	SteroidsIBA 08/01/2021 - "Randomized controlled trials between dorsal root ganglion thermal radiofrequency, pulsed radiofrequency and steroids for the management of intractable metastatic back pain in thoracic vertebral body." 08/01/2002 - "Statistically significant back pain relief was observed on postoperative days 1, 2, 6, and 14 in the study group (the group that received steroids). " 03/01/2024 - "Revolutionizing Back Pain Management: Is Epidural Platelet-Rich Plasma the Superior Choice Over Steroids?" 03/01/2022 - "A 29-year-old man developed altered mental status after receiving an epidural steroid injection 3 days earlier for back pain. " 04/01/2020 - "We retrospectively studied 51 patients with type 2 DM who underwent steroid injection for shoulder and back pain. "
4.	C-Reactive ProteinIBA 03/01/2024 - "The diagnostic performance was not significantly improved after combining clinical symptom (back pain) and laboratory indicators [erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP)]. " 11/01/2009 - "Immediately after the operation, we calculated a significant reduction of the back pain on the VAS to 1.7, of leukocyte counts and C-reactive protein levels. " 12/09/2017 - "He improved clinically, his back pain resolved, and C-reactive protein (CRP) decreased to normal. " 10/01/2019 - "A decrease in C-reactive protein (CRP) level, relief from back pain, and an increase in MSU crystal depositions were found in control patients. " 04/25/2018 - "For refractory lumbar and back pains, an elevated blood sedimentation rate, C-reactive protein level, MRI manifestation and focal pathology would be helpful for establishing a definite diagnosis. "
5.	Adrenal Cortex Hormones (Corticosteroids)IBA 01/01/2017 - "To explore the feasibility of running a RCT to test the hypothesis that, for people with suspected facet joint back pain, adding the option of intra-articular FJIs (local anaesthetic and corticosteroids) to best usual non-invasive care is clinically effective and cost-effective. " 01/01/2015 - "This is a case report of a very early onset of periaortitis after EVAR with inferior vena cava involvement and stretching, resulting in lower limb swelling and back pain, treated by corticosteroid drug with a good remission of the pathology. " 02/01/2019 - "One approach for the management of chronic back pain involves the injection of corticosteroids in the epidural space.This" 05/01/2005 - "In this case irradiation and corticosteroids relieved her leg and back pain. " 01/01/2017 - "Prospective survey study of women receiving outpatient corticosteroid injection for joint or back pain (cases) compared to women matched for visit, diagnosis of joint/back pain, and age, who did not receive an injection (controls). "
6.	Non-Steroidal Anti-Inflammatory Agents (NSAIDs)IBA 10/15/2000 - "Efficacy of NSAIDs have been demonstrated in acute back pain with randomised clinical trials. " 03/01/2024 - ""Any response" to NSAIDs was defined as improvement of back pain on the NRS > 2 units, and "good response" as improvement > 50%, compared to baseline. " 02/01/2023 - "This review addresses the practical aspects of the detailed evaluation of treatment attempts carried out so far with nonsteroidal anti-inflammatory drugs (NSAID) for back pain. " 01/01/2023 - "Treatment with non-steroidal anti-inflammatory drugs (NSAIDs) was initiated and led to alleviation of her back pain, although the thoracic spine lesions remained on the 6-month MRI. " 01/01/2021 - "Of 47,114 patients with chronic back pain, 3,620 (7.7%) had a reported NSAID ADR. "
7.	Teriparatide (Parathar)FDA Link 01/01/2016 - "EQ-5D scores and back pain VAS scores were significantly improved from baseline at each post-baseline observation during teriparatide treatment. " 01/01/2006 - "Teriparatide-treated patients had a reduced incidence of back pain versus those receiving a comparator during an observation encompassing clinical trials plus 30 months of posttreatment observation." 05/01/2013 - "A primary objective of this retrospective study was to define the efficacy of teriparatide in terms of bone mineral density (BMD) changes and relief of back pain in clinical practice. " 12/01/2016 - "This study reports the positive effect of osteoanabolic treatment with once-daily recombinant human parathyroid hormone 1-34 (rhPTH 1-34, teriparatide) in a 20-year-old DMD boy suffering from multiple vertebral fractures causing back pain. " 09/01/2012 - "The aims of this study were to evaluate the effectiveness of teriparatide treatment on back pain-related functional limitations and to investigate on patients HRQoL. "
8.	Anti-Bacterial Agents (Antibiotics)IBA 08/01/2013 - "Antibiotics a cure for back pain, a false dawn or a new era?" 12/01/2010 - "After antibiotic treatment, his back pain was improved and the patient was able to walk." 01/01/2017 - "These studies have served as the theoretical basis for a pilot trial, and then, a well done prospective randomized trial that demonstrated that systemic treatment with antibiotics may yield lasting improvements in a subset of patients with axial back pain. " 12/16/2022 - "Interventional surgery was combined with the use of sensitive antibiotics to relieve backache, and good clinical results were achieved. " 01/01/2022 - "The patient initially presented with back pain, inability to walk and severe neurological deficit in the upper and lower extremities, upon diagnosis broad-spectrum antibiotics were initiated. "
9.	Narcotics (Narcotic Analgesics)IBA 01/01/1983 - "Severe, persistent abdominal and back pain requiring narcotics is significantly relieved in approximately 80 percent of patients receiving a pancreatic drainage operation. " 05/01/2001 - "Back pain developed 3 years after the original bypass and was not relieved with narcotics and muscle relaxants. " 09/01/2015 - "Potential moderators with strong evidence (p<0.05) in one or more studies were age, employment status and type, back pain status, narcotic medication use, treatment expectations and education. " 03/01/2022 - "Randomization to receive the activL device was positively associated with better than the mean visual analog scale (VAS)-back pain and Oswestry Disability Index (ODI) scores, whereas preoperative narcotics use was negatively associated with better than the mean ODI score. " 05/01/2017 - "Specifically, there were significant increases in back pain dysfunction and narcotic medication usage in the current versus the past cohort. "
10.	Antidepressive Agents (Antidepressants)IBA 04/01/2007 - "Efficacy of noradrenergic and serotonergic antidepressants in chronic back pain: a preliminary concentration-controlled trial." 11/15/2003 - "To systematically review the efficacy of antidepressants for the treatment of patients with back pain and to determine whether there is evidence that outcomes vary between classes of antidepressants. " 11/15/2003 - "Three previous reviews have reached conflicting conclusions regarding the efficacy of antidepressants for patients with back pain. " 01/14/2002 - "To assess the efficacy of antidepressants in treating back pain in adults. " 01/01/2024 - "We identified eligible randomized controlled trials (RCTs) that investigated the efficacy and safety of antidepressants for chronic back pain from PubMed, Embase, the Cochrane Library, and ClinicalTrials.gov, searching from inception to May 2023. "

Therapies and Procedures

1.	Therapeutics 09/01/2021 - "Psychophysiologic symptom relief therapy is a feasible and potentially highly beneficial treatment for patients with nonspecific back pain." 01/01/2021 - "Our study shows that with comparable implementation of CT-guided periradicular therapy, the outcome of the patient with specific back pain can be significantly improved by certain behavioral patterns of the performing physician and this without side effects and without significant additional time expenditure. " 04/01/2020 - "To date, there are no Food and Drug Administration-approved intradiscal therapies for discogenic back pain, and there are no large randomized trials that have shown clinically significant improvement with any investigational regenerative treatment. " 01/01/2019 - "Intervertebral disc (IVD) degeneration, a major cause of back pain, is a particularly relevant example where a minimally-invasive cellular therapy could bring significant benefits specifically at the early stages of the disease, when a cell-driven process starts in the gelatinous core of the IVD, the nucleus pulposus (NP). " 03/01/2012 - "The medical food (Theramine) appeared to be effective in relieving back pain without causing any significant side effects and may provide a safe alternative to presently available therapies."
2.	Decompression 07/01/2009 - "Urgent posterior decompression was performed after 28 h from acute onset of backache, and the patient experienced remarkable improvement in neurological findings." 01/01/2017 - "Seventy-four percent of the fusion group and 63 % of the decompression alone group achieved a clinically important improvement in back pain (difference in proportion of responders = 11 %, 95 % CI 2-20 %, p = 0.01), corresponding to a number needed to treat of 9 patients (95 % CI 5-50). " 03/01/2013 - "The Isobar System after microsurgical decompression for lumbar degenerative disease provided excellent improvement in leg and back pain and patient satisfaction at late follow-up; however, evidence to suggest that Isobar outperforms traditional fusion is lacking. " 01/01/2023 - "Our study found that in the management of LSS, clinical outcomes between those patients undergoing decompression alone compared to decompression with ILD showed statistically significant improvement in VAS back pain and radiological parameters namely foraminal height and posterior disc height at the 5-year mark. " 10/01/2023 - "Patients undergoing lumbar decompression can be advised on the chance of a meaningful improvement in back pain postsurgery."
3.	Injections 08/01/2020 - "Water injections have no effect on birth outcomes though can be an effective treatment for the relief of labour-related back pain.Funded" 03/01/2020 - "Trigger point injections (TPIs) and acupuncture are common procedures in management of chronic back pain and usually are considered safe. " 11/01/2022 - "Recent trials demonstrated the safety and efficacy of sterile water injections to provide relief from labour back pain. " 01/01/2022 - "We evaluated whether injections targeted at foci with uptake on single-photon emission computerized tomography-computed tomography (SPECT-CT) were associated with improved outcomes in patients with chronic neck and back pain. " 07/01/2005 - "A sacroiliac fusion was undertaken due to chronic back pain that was temporarily relieved with percutaneous injections to the joint space and lower lumber facets. "
4.	Conservative Treatment 01/01/2014 - "Of those patients who fail conservative treatment, success with surgery is quite good, with significant improvement in neurologic function in those patients with deficits, as well as improvement in patients with back pain. " 09/01/2012 - " reviews of this procedure have shown significantly improved back pain and quality of life compared to conservative therapy. " 08/01/2010 - "Systematic reviews of both procedures have shown significantly improved back pain and quality of life compared to conservative therapy. " 01/01/2017 - "Implementation of the PT bundle appears to have led to a change in the treatment pattern of back pain that is more consistent with the recommended guidelines to use more conservative management such as PT as the first-line treatment for back pain." 01/01/2018 - "The specific approach appears to be effective in conservative treatment programs of back pain. "
5.	Vertebroplasty 06/01/2013 - "The back pain improved dramatically, and the patient was discharged two days after the vertebroplasty. " 01/01/2005 - "In well-selected patients, vertebroplasty offers rapid relief of axial back pain and the potential for improved function." 06/01/2005 - "Percutaneous vertebroplasty is a safe and effective procedure in relieving debilitating backache and can be used to treat vertebral lesions in selected cases." 05/01/2023 - "Patients with backpain - myelopathic symptoms had improved following surgery; patients with back pain alone had improved with either percutaneous vertebroplasty or CT guided alcohol ablation. " 06/01/2012 - "It was found that there was an immediate and sustainable improvement in the level of back pain and HRQoL after vertebroplasty, which was independent of the time from fracture. "