dihydrocodeine

RN refers to parent cpd(5alpha,6alpha)-isomer

Also Known As:

Contugesic; DF 118; DHC Continus; DHC Mundipharma; Dicodin; Paracodin; Paracodina; Rikodeine; Tiamon; Tosidrin; dihydrocodeine acetate, (5alpha,6alpha)-isomer; dihydrocodeine bitartrate; dihydrocodeine hydrochloride, (5alpha,6alpha)-isomer; dihydrocodeine phosphate (1:1), (5alpha,6alpha)-isomer; dihydrocodeine tartrate (1:1), (5alpha,6alpha)-(R-(R*,R*))-isomer; dihydrocodeine tartrate (1:1), (5alpha,6beta)-(R-(R*,R*))-isomer; dihydrocodeine, (5alpha,6alpha,14alpha)-isomer; dihydrocodeine, (5alpha,6beta)-isomer; dihydrocodeine, (5alpha,6beta,14alpha)-isomer; dihydrocodeine, thiocyanate salt (5alpha,6alpha)-isomer; paramol 118

Networked: 135 relevant articles (15 outcomes, 19 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Leppert, Wojciech: 6 articles (01/2012 - 01/2005)
2.	Yamazaki, Hiroshi: 3 articles (11/2019 - 01/2018)
3.	Archibong, Victor Bassey: 2 articles (01/2022 - 01/2021)
4.	Kamei, Junzo: 2 articles (01/2021 - 06/2002)
5.	Shimizu, Makiko: 2 articles (11/2019 - 01/2018)
6.	Li, Jun: 2 articles (05/2019 - 06/2018)
7.	Li, Yan: 2 articles (05/2019 - 06/2018)
8.	Long, Qing: 2 articles (05/2019 - 06/2018)
9.	Wan, Chuan: 2 articles (05/2019 - 06/2018)
10.	Wen, Yong: 2 articles (05/2019 - 06/2018)

Related Diseases

1.	Pain (Aches) 08/17/1982 - "The efficacy of dihydrocodeine in post-operative dental pain." 07/20/1982 - "The efficacy of dihydrocodeine in postoperative dental pain." 02/01/1967 - "Preliminary study of lupulin-dihydrocodeine in pain syndromes." 06/12/2018 - "The scores of anal pain VAS and limb activity at the 4th, 12th, 24th, 48th, 72th hours after operation were compared among the three groups, as well as the maximum scores of VAS in 24 hours (T24max VAS) of 1-3 days after operation, the total dose of aminophenol dihydrocodeine 72 h after operation. " 05/01/2014 - "A randomized, double-blind, double-dummy comparison of short- and long-acting dihydrocodeine in chronic non-malignant pain."
2.	Cough 04/24/1998 - "Dihydrocodeine at doses of 30 and 56 mg/kg, p.o., dose-dependently but not significantly reduced the number of allergic coughs. " 08/24/1988 - "The increased sensitivity to dihydrocodeine in terms of the depression of frequency of respiration and the cough reflex in 5,7-DHT-treated rats could possibly have been due to changes in the sensitivity of serotonergic receptors." 09/30/1971 - "[Clinical experiences with pentamethylentetrazole-dihydrocodeine in the therapy of cough in patients with pulmonary]." 08/24/1988 - "The present study sought to determine whether rats, treated neonatally with 5,7-dihydroxytryptamine (5,7-DHT), have an increased sensitivity to the respiratory and cough-depressant effects induced by dihydrocodeine. " 10/01/2012 - "cough syrup abuse - chlorpheniramine - dihydrocodeine."
3.	Postoperative Pain 01/01/2000 - "Fifty-two reports were identified as possible randomised trials which assessed dihydrocodeine in postoperative pain. " 01/01/2000 - "Single dose dihydrocodeine for acute postoperative pain." 05/01/1998 - "Postoperative pain was treated with 30 mg dihydrocodeine. " 01/01/2000 - "A single 30 mg dose of dihydrocodeine is not sufficient to provide adequate pain relief in postoperative pain. " 01/01/2000 - "To quantitatively assess the analgesic efficacy and adverse effects of single-dose dihydrocodeine compared with placebo in randomised trials in moderate to severe postoperative pain. "
4.	Dyspnea (Shortness of Breath) 01/01/1997 - "Its suppression with dihydrocodeine was associated with a reduction of exercise ventilation, an improvement in exercise tolerance and a decrease in breathlessness. " 04/16/1983 - "Dihydrocodeine for breathlessness in "pink puffers"." 03/26/1983 - "Dihydrocodeine for breathlessness in "pink puffers"." 02/26/1983 - "This benefit was confirmed by treadmill testing at the end of each treatment period, when maximum distance walked was 16.5% higher and breathlessness 11.8% less after dihydrocodeine compared with placebo. " 02/26/1983 - "During the weekly dihydrocodeine period patients were more mobile (pedometer distance increased by 16.8%) and less breathless (daily visual analogue score of breathlessness reduced by 17.8%). "
5.	Chronic Pain 07/01/1995 - "Dihydrocodeine retard (DHC) complies with the requirements for treatment of chronic pain: its sustained release formula provides pain relief for up to 12 h. " 07/01/1995 - "Insummary, the findings of this post marketing surveillance study suggest that sustained-release dihydrocodeine is an effective and safe analgesic drug for the treatment of chronic pain of various causes." 07/01/2010 - "Dihydrocodeine as an opioid analgesic for the treatment of moderate to severe chronic pain." 06/01/1997 - "Dihydrocodeine is increasingly used in slow-release preparations for the treatment of chronic pain on step 2 of the "analgesic ladder" of the World Health Organization. " 04/17/2021 - "Regression analysis showed that severe spinal cord injury and peri-treatment use of acetaminophen dihydrocodeine were both one of the risk factors for postoperative chronic pain. "

Related Drugs and Biologics

1.	Tablets
2.	Analgesics (Analgesic Drugs)
3.	dihydrocodeine
4.	Morphine (MS Contin)
5.	Codeine (Codeine Phosphate)
6.	Opioid Analgesics (Opioids)
7.	Dextropropoxyphene (Darvon)
8.	Methadone (Dolophine)
9.	dipropizine (dropropizine)
10.	Buprenorphine (Subutex)

Related Therapies and Procedures

1.	Oral Administration
2.	Analgesia
3.	Oral Surgery (Maxillofacial Surgery)
4.	Intravenous Administration
5.	Opiate Substitution Treatment