[Cytokine in cancer chemotherapy--clinical trials of IL-3, IL-11 and thrombopoietin against thrombocytopenia].

Abstract

Clinical trials of IL-3, IL-11 and thrombopoietin (TPO) against chemotherapy-induced thrombocytopenia were reviewed. Many clinical trials of IL-3 were conducted, which increased the platelet nadir counts and improved the recovery from thrombocytopenia at a dose of 5 micrograms/kg/day for 7 to 14 days. Major side effects, fever and headache, were tolerable. The combination with G-CSF was also examined. IL-11 improved the platelet nadir counts and the recovery from thrombocytopenia at a dose of 50 micrograms/kg/day for 14 days. Adverse events of IL-11 were general fatigue and edema, which were mild. Phase I/II studies of TPO were conducted, which showed a marked increase of platelet counts and improvement in recovery from thrombocytopenia. A few patients experienced mild thrombo-embolism. Improved QOL and survival benefits in the evaluation of these cytokines must be demonstrated.

• Authors: S Kudoh, M Yamada
• Journal: Gan to kagaku ryoho. Cancer & chemotherapy (Gan To Kagaku Ryoho) Vol. 25 Issue 2 Pg. 171-6 (Jan 1998) ISSN: 0385-0684 [Print] Japan
• PMID: 9474925 (Publication Type: English Abstract, Journal Article, Review)

Chemical References

• Interleukin-11
• Interleukin-3
• Granulocyte Colony-Stimulating Factor
• Thrombopoietin
• Carboplatin
• Paclitaxel

Topics

• Antineoplastic Combined Chemotherapy Protocols (adverse effects)
• Carboplatin (adverse effects)
• Carcinoma, Non-Small-Cell Lung (blood, drug therapy)
• Clinical Trials as Topic
• Clinical Trials, Phase II as Topic
• Drug Administration Schedule
• Granulocyte Colony-Stimulating Factor (administration & dosage)
• Humans
• Interleukin-11 (administration & dosage)
• Interleukin-3 (administration & dosage)
• Lung Neoplasms (blood, drug therapy)
• Paclitaxel (adverse effects)
• Platelet Count
• Randomized Controlled Trials as Topic
• Thrombocytopenia (chemically induced, therapy)
• Thrombopoietin (administration & dosage)
• United States