Abstract |
HLA class II analysis in a group of 153 Czech children with juvenile rheumatoid arthritis by PCR and oligonucleotide hybridization demonstrated associations with several alleles. DRB1*0801 (RR = 5.3, p < 0.005) and DRB1 * 11 (RR = 2.2, p < 0.01) including all subtypes were shown to be increased in the rheumatoid factor-negative group (N = 137). The same results were observed in Italy, England and Norway. In patients with the pauciarticular onset with conversion to polyarticular within 3 years, a statistically significant increase in DR2 (RR = 10.1, p < 0.00005), mostly due to DRB1*1501, was found. In the iridocyclitis and antinuclear factor groups, susceptibility to DRB1*1201 was observed. There was a striking decrease in DRB1*0701 (RR = 0.3, p < 0.00005) in all groups. There was neither an increase in DRB1*1301 or DPB1*0301 nor a decrease in DRB1*04, as reported from other studies in Texas and Norway. The rheumatoid factor-positive group with polyarticular onset (N = 13) was associated with DRB1*04 (RR = 7.1, p < 0.005), as observed in adults. DPB1*0201 was increased in the persistent pauciarticular group (RR = 3.7, p < 0.0005). DPB1*0402 was decreased in all pauciarticular groups with or without conversion (RR = 0.3, p < 0.005). Taken together, there are not only genetic differences and clinical heterogeneity in juvenile rheumatoid arthritis patients but, also, common predisposing factors.
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Authors | M Cerná, P Vavrincová, S Havelka |
Journal | Acta Universitatis Carolinae. Medica
(Acta Univ Carol Med (Praha))
Vol. 40
Issue 1-4
Pg. 69-73
( 1994)
ISSN: 0001-7116 [Print] Czech Republic |
PMID | 9355676
(Publication Type: Journal Article)
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Chemical References |
- HLA-D Antigens
- HLA-DP Antigens
- HLA-DP beta-Chains
- HLA-DPB1 antigen
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Topics |
- Adult
- Alleles
- Amino Acid Sequence
- Arthritis, Juvenile
(genetics, immunology)
- Child
- Czech Republic
- Genes, MHC Class II
- HLA-D Antigens
(genetics)
- HLA-DP Antigens
(genetics)
- HLA-DP beta-Chains
- Humans
- Molecular Sequence Data
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