Interleukin-4 blocks the release of collagen fragments from bovine nasal cartilage treated with cytokines.

Abstract	Interleukin-1 (IL-1) in combination with other cytokines can induce a reproducible release of collagen fragments from bovine nasal cartilage in culture. Over 70% of the total collagen is released by day 14 and this release is accompanied by the appearance of collagenolytic activity in the medium that cleaves collagen specifically at the one quarter/three quarter position. Interleukin-4 is able to prevent the release of collagen fragments from the tissue and this is accompanied by a reduced secretion and activation of collagenase (MMP-1) with an increase in tissue inhibitor of metalloproteinases-1 (TIMP-1). IL-4, especially in the presence of IL-1, increased TIMP secretion by bovine nasal cartilage in culture. These results suggest that IL-4 is able to specifically block cartilage collagen resorption by down-regulating the production of collagenase (MMP-1) and up-regulating TIMP-1 by chondrocytes within the cartilage.
Authors	T E Cawston, A J Ellis, H Bigg, V Curry, E Lean, D Ward
Journal	Biochimica et biophysica acta (Biochim Biophys Acta) Vol. 1314 Issue 3 Pg. 226-32 (Dec 12 1996) ISSN: 0006-3002 [Print] Netherlands
PMID	8982276 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Cytokines Enzyme Precursors Glycoproteins Glycosaminoglycans Matrix Metalloproteinase Inhibitors Peptide Fragments Peptides Protease Inhibitors Tissue Inhibitor of Metalloproteinases Oncostatin M Interleukin-10 Interleukin-4 Collagen Collagenases procollagenase
Topics	Animals Cattle Collagen (metabolism) Collagenases (metabolism) Cytokines (pharmacology) Enzyme Precursors (metabolism) Glycoproteins (biosynthesis) Glycosaminoglycans (metabolism) In Vitro Techniques Interleukin-10 (pharmacology) Interleukin-4 (pharmacology) Matrix Metalloproteinase Inhibitors Nasal Septum (metabolism) Oncostatin M Peptide Fragments (metabolism) Peptides (pharmacology) Protease Inhibitors Tissue Inhibitor of Metalloproteinases

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