Cyclic change of cytokines in a patient with cyclic thrombocytopenia.

Abstract

The serial change of various cytokines in the serum from a patient with cyclic thrombocytopenia is described. Interleukin 7, stem cell factor, and transforming growth factor beta 1 synchronized with the platelet count, and there was a significant positive correlation between the three cytokines and the platelet count. Levels of macrophage colony-stimulating factor, thrombopoietin, platelet-associated IgG and erythropoietin changed reciprocally with the platelet count, and there was a significant negative correlation between the platelet count and these cytokines except erythropoietin. No cyclic change was observed in IL-3, IL-6, IL-11, granulocyte-macrophage colony-stimulating factor, or leukaemia inhibitory factor. These observations suggest that this disease involves two cyclic changes: megakaryocytopoiesis and platelet destruction, in both of which the cytokines play an important role.

• Authors: F Kimura, Y Nakamura, K Sato, N Wakimoto, T Kato, T Tahara, M Yamada, N Nagata, K Motoyoshi
• Journal: British journal of haematology (Br J Haematol) Vol. 94 Issue 1 Pg. 171-4 (Jul 1996) ISSN: 0007-1048 [Print] England
• PMID: 8757531 (Publication Type: Case Reports, Journal Article)

Chemical References

• Interleukin-7
• Stem Cell Factor
• Macrophage Colony-Stimulating Factor
• Thrombopoietin

Topics

• Adult
• Humans
• Interleukin-7 (metabolism)
• Macrophage Colony-Stimulating Factor (metabolism)
• Male
• Periodicity
• Platelet Count
• Stem Cell Factor (metabolism)
• Thrombocytopenia (metabolism)
• Thrombopoietin (metabolism)