Abstract | PURPOSE: PATIENTS AND METHODS: RESULTS: The patient with Morquio's disease failed to engraft but underwent a successful retransplantation from the same donor. All patients eventually demonstrated donor engraftment and the donor's hemoglobin electrophoretic pattern posttransplant. Two patients had moderately severe GVHD of the skin and gastrointestinal tract, which resolved with prednisone therapy. One of these patients developed transient chronic GVHD involving the skin. Other acute complications included mild venoocclusive disease of the liver, central line infection with bacteremias, uterine hemorrhage in one patient, and pseudomonas sepsis in another. CONCLUSIONS: Both patients who underwent transplantation after CVAs have experienced subsequent neurological events. However, with a median follow-up of 16 months (range 8 months to 9.3 years), all patients are surviving in good to excellent clinical condition and appear to have benefitted from treatment by bone marrow transplantation.
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Authors | F L Johnson, W C Mentzer, K A Kalinyak, K M Sullivan, M R Abboud |
Journal | The American journal of pediatric hematology/oncology
(Am J Pediatr Hematol Oncol)
Vol. 16
Issue 1
Pg. 22-6
(Feb 1994)
ISSN: 0192-8562 [Print] United States |
PMID | 8311168
(Publication Type: Journal Article)
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Topics |
- Adolescent
- Anemia, Sickle Cell
(therapy)
- Bone Marrow Transplantation
(adverse effects)
- Child
- Child, Preschool
- Female
- Graft vs Host Disease
(etiology)
- Humans
- Male
- United States
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