Etidocaine in retrobulbar anaesthesia. A comparison with mepivacaine.

Abstract

A new long-acting local anaesthetic, etidocaine (Duranest) has been compared to mepivacaine (Carbocaine) in retrobulbar anaesthesia in a double-blind trial including 45 patients. Solutions used were etidocaine 0.5% and 1% and mepivacaine 1%, all without adrenaline. The onset time was short and no difference was found between the solutions. The duration of analgesia and motor block was significantly longer with etidocaine 1% compared to mepivacaine 1%. In a following open study with etidocaine 1% and mepivacaine 1% about 80% of the the patients in the etidocaine group never experienced any post-operative pain compared to about 50% in the mepivacaine group. No signs of local or systemic toxicity were noted in the studies.

• Authors: W Thorburn, A M Thorn-Alquist, H Edström
• Journal: Acta ophthalmologica (Acta Ophthalmol (Copenh)) Vol. 54 Issue 5 Pg. 591-600 (Oct 1976) ISSN: 0001-639X [Print] Denmark
• PMID: 790888 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Acetanilides
• Mepivacaine
• Etidocaine

Topics

• Acetanilides (analogs & derivatives)
• Adult
• Aged
• Anesthesia, Local
• Cataract Extraction
• Clinical Trials as Topic
• Drug Evaluation
• Etidocaine
• Eye Movements
• Glaucoma (surgery)
• Humans
• Mepivacaine
• Middle Aged
• Ophthalmologic Surgical Procedures
• Postoperative Complications
• Time Factors