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Unstable methotrexate resistance in human small-cell carcinoma associated with double minute chromosomes.

AuthorsG A Curt, D N Carney, K H Cowan, J Jolivet, B D Bailey, J C Drake, K S Chien Song, J D Minna, B A Chabner
JournalThe New England journal of medicine (N Engl J Med) Vol. 308 Issue 4 Pg. 199-202 (Jan 27 1983) ISSN: 0028-4793 [Print] United States
PMID6294518 (Publication Type: Journal Article)
Chemical References
  • DNA, Neoplasm
  • Methotrexate
Topics
  • Carcinoma, Small Cell (drug therapy, genetics)
  • Cell Line
  • DNA, Neoplasm (genetics)
  • Drug Resistance
  • Gene Amplification
  • Humans
  • Lung Neoplasms (drug therapy, genetics)
  • Methotrexate (therapeutic use)
  • Mutation

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