Anti-Obesity Effect and Signaling Mechanism of Potassium Poly-γ-Glutamate Produced by Bacillus subtilis Chungkookjang in High-Fat Diet-Induced Obese Mice.
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| Abstract |
The purpose of this work was to examine the effects of potassium poly-γ-glutamate (PGA-K) on mice fed a high-fat diet consisting of 60% of total calories for 12 weeks. PGA-K administration reduced the increase in body weight, epididymal fat, and liver weight caused by a high-fat diet compared to the obese group. The triglyceride, low-density lipoprotein cholesterol and high-density lipoprotein cholesterol levels, which are blood lipid indicators, were significantly increased in the obese group but were significantly decreased in the PGA-K-treated group. The administration of PGA-K resulted in a significant inhibition of pro-inflammatory cytokines, including tumor necrosis factor α and interleukin 6. Moreover, the levels of leptin and insulin, which are insulin resistance indicators, significantly increased in the obese group but were significantly decreased in the PGA-K-treated group. These results suggest that PGA-K exhibits a protective effect against obesity induced by a high-fat diet, underscoring its potential as a candidate for obesity treatment.
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| Authors | Seung-Hyeon Lee, Jiwon Choi, Jae Young Park, Ha-Rim Kim, Myeongkuk Shim, Kyunghyun Im, Hyeonjeong Choe, Jae-Chul Choi, Young-Chul Park, Tae-Gyu Lim, Hyangyim Seo, Hansu Jang, Boung-Jun Oh, Seon-Young Kim, Mi Hee Park |
| Journal | Nutrients (Nutrients) Vol. 16 Issue 6 (Mar 12 2024) ISSN: 2072-6643 [Electronic] Switzerland |
| PMID | 38542720 (Publication Type: Journal Article) |
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