Deciphering adipose development: Function, differentiation and regulation.

Abstract

The overdevelopment of adipose tissues, accompanied by excess lipid accumulation and energy storage, leads to adipose deposition and obesity. With the increasing incidence of obesity in recent years, obesity is becoming a major risk factor for human health, causing various relevant diseases (including hypertension, diabetes, osteoarthritis and cancers). Therefore, it is of significance to antagonize obesity to reduce the risk of obesity-related diseases. Excess lipid accumulation in adipose tissues is mediated by adipocyte hypertrophy (expansion of pre-existing adipocytes) or hyperplasia (increase of newly-formed adipocytes). It is necessary to prevent excessive accumulation of adipose tissues by controlling adipose development. Adipogenesis is exquisitely regulated by many factors in vivo and in vitro, including hormones, cytokines, gender and dietary components. The present review has concluded a comprehensive understanding of adipose development including its origin, classification, distribution, function, differentiation and molecular mechanisms underlying adipogenesis, which may provide potential therapeutic strategies for harnessing obesity without impairing adipose tissue function.

• Authors: Ge Guo, Wanli Wang, Mengjie Tu, Binbin Zhao, Jiayang Han, Jiali Li, Yanbing Pan, Jie Zhou, Wen Ma, Yi Liu, Tiantian Sun, Xu Han, Yang An
• Journal: Developmental dynamics : an official publication of the American Association of Anatomists (Dev Dyn) (Mar 22 2024) ISSN: 1097-0177 [Electronic] United States
• PMID: 38516819 (Publication Type: Journal Article, Review)
• Copyright: © 2024 American Association for Anatomy.