Tissue-resident memory T cells exhibit phenotypically and functionally heterogeneous in human physiological and pathological nasal mucosa.

Abstract

Pathogens commonly enter mucosal barrier tissues and tissue-resident memory T cells (TRM) are essential for preventing mucosal lesions. However, the immunological properties of TRM cells in nasal mucosa are poorly known. In comparison with control tissues, decreasing CD103+ TRM cells were observed in Chronic rhinosinusitis with nasal polyps (CRSwNPs) and sinonasal inverted papilloma (SNIP), which presented high capability to produce effector cytokines. In CRSwNPs, we found that CD103+ TRM cells with higher cytokine and Granzyme B coexpressed high PD-1, CD103- TRM cells expressed higher IL-10. Homogenates isolated from CRSwNPs induced CD103 expression on peripheral T cells which could be inhibited by blocking TGF-β. The frequencies of CD103+ TRM cells in CRSwNPs were extremely negatively correlated with neutrophil infiltration. CD103+ TRM cells from Staphylococcus aureus positive CRSwNPs had a stronger response to SEB. Taken together, two phenotypically and functionally distinct subsets of TRM cells exist in nasal tissues and play critical roles in the progress of CRSwNPs and SNIPs.

• Authors: Sifei Yu, Kai Wang, Chen Cao, Beiying Zhang, Youmou Chen, Changyou Wu, Chunwei Li, Jun Tang, Wei Luo
• Journal: Clinical immunology (Orlando, Fla.) (Clin Immunol) Vol. 258 Pg. 109860 (01 2024) ISSN: 1521-7035 [Electronic] United States
• PMID: 38065369 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2023. Published by Elsevier Inc.

Chemical References

• Cytokines

Topics

• Humans
• CD8-Positive T-Lymphocytes
• Memory T Cells
• Immunologic Memory
• Neoplasms
• Cytokines (metabolism)
• Nasal Mucosa (metabolism)