Abstract |
Oral ulcer can be treated with diverse biomaterials loading drugs or cytokines. However, most patients do not benefit from these materials because of poor adhesion, short-time retention in oral cavity and low drug therapeutic efficacy. Here we report a self-stabilized and water-responsive deliverable coenzyme salt polymer poly( sodium α-lipoate) (PolyLA-Na)/ coenzyme polymer poly(α- lipoic acid) (PolyLA) binary synergistic elastomer adhesive patch, where hydrogen bonding cross-links between PolyLA and PolyLA-Na prevents PolyLA depolymerization and slow down the dissociation of PolyLA-Na, thus allowing water-responsive sustainable delivery of bioactive LA-based small molecules and durable adhesion to oral mucosal wound due to the adhesive action of PolyLA. In the model of mice and mini-pig oral ulcer, the adhesive patch accelerates the healing of the ulcer by regulating the damaged tissue inflammatory environment, maintaining the stability of oral microbiota, and promoting faster re-epithelialization and angiogenesis. This binary synergistic patch provided a therapeutic strategy to treat oral ulcer.
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Authors | Chunyan Cui, Li Mei, Danyang Wang, Pengfei Jia, Qihui Zhou, Wenguang Liu |
Journal | Nature communications
(Nat Commun)
Vol. 14
Issue 1
Pg. 7707
(Nov 24 2023)
ISSN: 2041-1723 [Electronic] England |
PMID | 38001112
(Publication Type: Journal Article)
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Copyright | © 2023. The Author(s). |
Chemical References |
- Polymers
- Adhesives
- Elastomers
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Topics |
- Humans
- Animals
- Swine
- Oral Ulcer
(drug therapy)
- Polymers
- Adhesives
- Elastomers
- Swine, Miniature
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