Myasthenia gravis: Molecular mechanisms and promising therapeutic strategies.

Abstract

Myasthenia gravis (MG) is a type of autoimmune disease caused by the blockage of neuromuscular junction transmission owing to the attack of autoantibodies on transmission-related proteins. Related antibodies, such as anti-AChR, anti-MuSK and anti-LRP4 antibodies, can be detected in most patients with MG. Although traditional therapies can control most symptoms, several challenges remain to be addressed, necessitating the development of more effective and safe treatment strategies for MG. With the in-depth exploration on the mechanism and immune targets of MG, effective therapies, especially therapies using biologicals, have been reported recently. Given the important roles of immune cells, cytokines and intercellular interactions in the pathological process of MG, B-cell targeted therapy, T-cell targeted therapy, proteasome inhibitors targeting plasma cell, complement inhibitors, FcRn inhibitors have been developed for the treatment of MG. Although these novel therapies exert good therapeutic effects, they may weaken the immunity and increase the risk of infection in MG patients. This review elaborates on the pathogenesis of MG and discusses the advantages and disadvantages of the strategies of traditional treatment and biologicals. In addition, this review emphasises that combined therapy may have better therapeutic effects and reducing the risk of side effects of treatments, which has great prospects for the treatment of MG. With the deepening of research on immunotherapy targets in MG, novel opportunities and challenges in the treatment of MG will be introduced.

• Authors: Xin Chen, Jiayi Qiu, Zihui Gao, Boya Liu, Chen Zhang, Weiran Yu, Jiawen Yang, Yuntian Shen, Lei Qi, Xinlei Yao, Hualin Sun, Xiaoming Yang
• Journal: Biochemical pharmacology (Biochem Pharmacol) Vol. 218 Pg. 115872 (12 2023) ISSN: 1873-2968 [Electronic] England
• PMID: 37865142 (Publication Type: Journal Article, Review, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2023 Elsevier Inc. All rights reserved.

Chemical References

• Receptor Protein-Tyrosine Kinases
• Autoantibodies

Topics

• Humans
• Receptor Protein-Tyrosine Kinases (metabolism)
• Myasthenia Gravis (drug therapy, diagnosis)
• Neuromuscular Junction (metabolism)
• Autoantibodies (metabolism)
• Immunotherapy