High-Sucrose Diet Accelerates Arthritis Progression in a Collagen-Induced Rheumatoid Arthritis Model.

Abstract

SCOPE:

High dietary sugar and sweeteners are suspected to cause the development of rheumatoid arthritis (RA) symptoms through the induction of proinflammatory cytokine release. However, the mechanisms by which increased dietary sugar affects RA etiology are not yet fully understood. The study uses a mouse model of collagen-induced RA (CIA) to investigate the relationship between excessive sugar consumption and RA risk.

METHODS AND RESULTS:

RA-associated pathological features are assessed in the nonimmunized (NI) control group, the CIA-positive control group, and the CIA + high-sucrose diet (CIA+HS, 63% calories from sucrose) group. Compared with the CIA group, the CIA+HS group shows a greater increase in paw thickness and clinical scores, as well as, a higher degree of pannus formation and inflammation in the knee, ankle, and sole tissues. Moreover, the infiltration of immune cells is increased in the CIA+HS group. Although the expression of hepatic lipogenic genes, is not altered, that of toll-like receptor (TLR4) and IL-1β is considerably elevated in the CIA+HS group.

CONCLUSIONS:

These findings suggest that excessive sucrose consumption causes hepatic fibrosis and inflammation, contributing to the pathophysiology of RA.

• Authors: Yunhui Min, Yunji Heo, Fang Feng, Dahye Kim, Mangeun Kim, Jiwon Yang, Hyo Jin Kim, Youngheun Jee, Mrinmoy Ghosh, Inhae Kang, Young-Ok Son
• Journal: Molecular nutrition & food research (Mol Nutr Food Res) Vol. 67 Issue 20 Pg. e2300244 (10 2023) ISSN: 1613-4133 [Electronic] Germany
• PMID: 37688304 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2023 Wiley-VCH GmbH.

Chemical References

• Sucrose
• Collagen
• Dietary Sugars

Topics

• Mice
• Animals
• Sucrose (adverse effects)
• Arthritis, Experimental (etiology)
• Arthritis, Rheumatoid (pathology)
• Inflammation (pathology)
• Collagen
• Diet (adverse effects)
• Dietary Sugars (adverse effects)