Modified Korean MIND Diet: A Nutritional Intervention for Improved Cognitive Function in Elderly Women through Mitochondrial Respiration, Inflammation Suppression, and Amino Acid Metabolism Regulation.

Abstract

SCOPE:

Mild cognitive impairment is associated with a high prevalence of dementia. The study examines the benefits of a modified Korean MIND (K-MIND) diet and explores biomarkers using multi-omics analysis.

METHODS AND RESULTS:

The K-MIND diet, tailored to the elderly Korean population, includes perilla oil, milk, or fermented milk, and avoids alcohol consumption. As a result, the K-MIND diet significantly improves subjects "orientation to place" in the Korean version of the Mini-Mental State Examination, 2nd edition test. According to multi-omics analysis, the K-MIND diet upregulates genes associated with mitochondrial respiration, including ubiquinone oxidoreductase, cytochrome C oxidase, and ATP synthase, and immune system processes, and downregulates genes related to nuclear factor kappa B activity and inflammatory responses. In addition, K-MIND affects the metabolic pathways of glycine, serine, threonine, tryptophan, and sphingolipids, which are closely linked to cognitive function through synthesis of neurotransmitters and structures of brain cell membranes.

CONCLUSION:

The findings imply that the K-MIND diet improves cognitive function by upregulating key genes involved in oxidative phosphorylation and downregulating pro-inflammatory cytokines.

• Authors: Eun Young Kang, Do-Young Kim, Hyun Kyung Kim, Tae Hoon Kim, Wooki Kim, Cao Lei, Sang-Gil Lee, Gyoungok Gang, Minhye Shin, Jun-Mo Kim, Gwang-Woong Go
• Journal: Molecular nutrition & food research (Mol Nutr Food Res) Vol. 67 Issue 20 Pg. e2300329 (10 2023) ISSN: 1613-4133 [Electronic] Germany
• PMID: 37650267 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2023 Wiley-VCH GmbH.

Chemical References

• Amino Acids

Topics

• Humans
• Female
• Aged
• Amino Acids
• Cognition
• Diet
• Inflammation
• Republic of Korea