Abstract | Introduction: Methods: Therefore, this paper aims to identify miRNAs that are potentially associated with colon cancer and regulate a large number of genes related to immune function. We explored the role of these genes in colon cancer patient prognosis, immune infiltration, and tumor purity based on data of 174 colon cancer patients though convolutional neural network, survival analysis and multiple analysis tools. Results: Our findings suggest that miRNA regulated genes play important roles in CD4 memory resting cells, macrophages.M2, and Mast cell activated cells, and they are concentrated in the cytokinecytokine receptor interaction pathway. Discussion: Our study enhances our understanding of the underlying mechanisms of intestinal cancer and provides new insights into the development of effective therapies. Additionally, identification of miRNA biomarkers could aid in diagnosis and prognosis, as well as guide personalized treatment strategies for patients with intestinal cancer.
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Authors | Lu Han, Shiyun Chen, Zhe Luan, Mengjiao Fan, Yanrong Wang, Gang Sun, Guanghai Dai |
Journal | Frontiers in immunology
(Front Immunol)
Vol. 14
Pg. 1203070
( 2023)
ISSN: 1664-3224 [Electronic] Switzerland |
PMID | 37465677
(Publication Type: Journal Article)
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Copyright | Copyright © 2023 Han, Chen, Luan, Fan, Wang, Sun and Dai. |
Chemical References |
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Topics |
- Humans
- MicroRNAs
(genetics, metabolism)
- Colonic Neoplasms
(genetics)
- Biomarkers
- Immunity
- Tumor Microenvironment
(genetics)
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